Heptanenitrile, 2-hydroxy-7-(triphenylmethoxy)-

Base Information

• Chemical Name: Heptanenitrile, 2-hydroxy-7-(triphenylmethoxy)-
• CAS No.: 804556-39-6
• Molecular Formula: C26H27NO2
• Molecular Weight: 385.506
• Mol file: 804556-39-6.mol

Synonyms:

Chemical Property of Heptanenitrile, 2-hydroxy-7-(triphenylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Heptanenitrile, 2-hydroxy-7-(triphenylmethoxy)-

There total 3 articles about Heptanenitrile, 2-hydroxy-7-(triphenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

potassium cyanide (151-50-8) + 6-trityloxyhexanal (804556-25-0) → (+/-)-2-hydroxy-7-trityloxyheptanenitrile (804556-39-6)

Guidance literature:

With sodium hydrogensulfite; In water; at 0 ℃; for 20h;

DOI:10.1016/j.tet.2004.06.134

Reference yield:

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) → (+/-)-2-hydroxy-7-trityloxyheptanenitrile (804556-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: DIBAL-H / tetrahydrofuran; toluene / 8 h / -70 °C

1.2: hydrochloric acid; water / tetrahydrofuran; toluene / 20 °C

2.1: 5.92 g / pyridine / 10 h / 75 °C

3.1: 57 percent / sodium hydrogen sulfite / H₂O / 20 h / 0 °C

With pyridine; diisobutylaluminium hydride; sodium hydrogensulfite; In tetrahydrofuran; water; toluene;

DOI:10.1016/j.tet.2004.06.134

Reference yield:

6-hydroxyhexanal (34067-76-0) → (+/-)-2-hydroxy-7-trityloxyheptanenitrile (804556-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.92 g / pyridine / 10 h / 75 °C

2: 57 percent / sodium hydrogen sulfite / H₂O / 20 h / 0 °C

With pyridine; sodium hydrogensulfite; In water;

DOI:10.1016/j.tet.2004.06.134

upstream raw materials:

potassium cyanide

6-trityloxyhexanal

hexahydro-2H-oxepin-2-one

6-hydroxyhexanal

Refernces