N-[(Z)-(4-nitrophenyl)methylideneamino]pyridine-4-carboxamide

Base Information

• Chemical Name: N-[(Z)-(4-nitrophenyl)methylideneamino]pyridine-4-carboxamide
• CAS No.: 4813-07-4
• Molecular Formula: C13H10N4O3
• Molecular Weight: 270.247
• NSC Number: 50112
• Nikkaji Number: J899.577J
• Mol file: 4813-07-4.mol

Synonyms:NSC50112;MLS002667329;NSC-50112

Chemical Property of N-[(Z)-(4-nitrophenyl)methylideneamino]pyridine-4-carboxamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.33g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 270.07529019
• Heavy Atom Count: 20
• Complexity: 366

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=NNC(=O)C2=CC=NC=C2)[N+](=O)[O-]
• Isomeric SMILES: C1=CC(=CC=C1/C=N\NC(=O)C2=CC=NC=C2)[N+](=O)[O-]

Technology Process of N-[(Z)-(4-nitrophenyl)methylideneamino]pyridine-4-carboxamide

There total 3 articles about N-[(Z)-(4-nitrophenyl)methylideneamino]pyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

isoniazid (54-85-3,7640-37-1) + 4-nitrobenzaldehdye (555-16-8) → (E)-N'-(4-nitrobenzylidene)isonicotinohydrazide (4813-07-4)

Guidance literature:

With trifluoroacetic acid; In ethanol; Reflux;

DOI:10.1021/jacs.5b09519

Reference yield:

N'-[(Z)-(4-nitrophenyl)methylidene]pyridine-4-carbohydrazide (1262213-16-0) → (E)-N'-(4-nitrobenzylidene)isonicotinohydrazide (4813-07-4)

Guidance literature:

In acetonitrile; at 25 ℃; for 1.83333h; Irradiation;

DOI:10.1021/jacs.5b09519

Reference yield:

→ (E)-N'-(4-nitrobenzylidene)isonicotinohydrazide (4813-07-4)

Guidance literature:

DOI:10.1007/BF00921836

upstream raw materials:

isoniazid

4-nitrobenzaldehdye

N'-[(Z)-(4-nitrophenyl)methylidene]pyridine-4-carbohydrazide

Downstream raw materials:

N'-[(Z)-(4-nitrophenyl)methylidene]pyridine-4-carbohydrazide