1H-Indole-1-acetic acid, 5-[(2',6'-dimethyl[1,1'-biphenyl]-3-yl)methoxy]-

Base Information

Chemical Name:1H-Indole-1-acetic acid, 5-[(2',6'-dimethyl[1,1'-biphenyl]-3-yl)methoxy]-
CAS No.:805249-15-4
Molecular Formula:C25H23NO3
Molecular Weight:385.463
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indole-1-acetic acid, 5-[(2',6'-dimethyl[1,1'-biphenyl]-3-yl)methoxy]-

Chemical Property:

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Technology Process of 1H-Indole-1-acetic acid, 5-[(2',6'-dimethyl[1,1'-biphenyl]-3-yl)methoxy]-

There total 6 articles about 1H-Indole-1-acetic acid, 5-[(2',6'-dimethyl[1,1'-biphenyl]-3-yl)methoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 805249-14-3
ethyl {5-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-1H-indole-1-yl}acetate

: 805249-15-4
{5-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-1H-indole-1-yl}acetic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 18h;
DOI:10.1021/jm2012968

Reference yield:

: 691905-26-7
2',6'-dimethyl-[1,1'-biphenyl]-3-carbaldehyde

: 805249-15-4
{5-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-1H-indole-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 0 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 20 °C

3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.33 h / 4 °C / Inert atmosphere

3.2: 48 h / 4 - 20 °C

4.1: potassium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C

With sodium tetrahydroborate; tributylphosphine; sodium hydride; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2012968

Reference yield:

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 805249-15-4
{5-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-1H-indole-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / Reflux

2.1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 0 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 20 °C

4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.33 h / 4 °C / Inert atmosphere

4.2: 48 h / 4 - 20 °C

5.1: potassium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; sodium hydride; sodium carbonate; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki coupling / 3.1: Mitsunobu reaction;
DOI:10.1021/jm2012968