2-AMino-5,6-dihydro-4H-benzothiazol -7-one hydrobroMide

Base Information

• Chemical Name: 2-AMino-5,6-dihydro-4H-benzothiazol -7-one hydrobroMide
• CAS No.: 805250-54-8
• Molecular Formula: 2BrH*C₇H₈N₂OS
• Molecular Weight: 330.043
• Hs Code.: 2934200090
• Mol file: 805250-54-8.mol

Synonyms:QC-8519;2-Amino-5,6-dihydro-4H-benzothiazol-7-one hydrobromide;

Chemical Property of 2-AMino-5,6-dihydro-4H-benzothiazol -7-one hydrobroMide

Chemical Property:

• PSA: 84.95000
• LogP: 2.13250

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5,6-dihydro-7(4H)-benzothiazoloneHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of dihydrobenzofuranacetic as antidiabetic agents.

Technology Process of 2-AMino-5,6-dihydro-4H-benzothiazol -7-one hydrobroMide

There total 2 articles about 2-AMino-5,6-dihydro-4H-benzothiazol -7-one hydrobroMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-cylohexanedione (504-02-9) → 2-amino-5,6-dihydrobenzothiazol-7(4H)-one dihydrobromide (805250-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 4 h

2: ethanol / 3 h / Reflux; Inert atmosphere

With bromine; acetic acid; In ethanol;

DOI:10.1021/acs.oprd.6b00182

Reference yield:

2-bromocyclohexane-1,3-dienone (60060-44-8) + thiourea (17356-08-0) → 2-amino-5,6-dihydrobenzothiazol-7(4H)-one dihydrobromide (805250-54-8)

Guidance literature:

In ethanol; for 3h; Reflux;

DOI:10.1016/j.bmcl.2010.07.098

Reference yield:

2-amino-5,6-dihydrobenzothiazol-7(4H)-one dihydrobromide (805250-54-8) → 2-amino-6-azido-5,6-dihydrobenzothiazol-7(4H)-one

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; trimethyl orthoformate / methanol / 18 - 23 °C

1.2: 0 - 20 °C

2.1: sodium azide / N,N-dimethyl-formamide; water / 20 °C

With sodium azide; sulfuric acid; trimethyl orthoformate; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.oprd.6b00182

upstream raw materials:

2-bromocyclohexane-1,3-dienone

thiourea

1,3-cylohexanedione

Downstream raw materials:

(6S,7R)-N6-propyl-N7-((S)-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol-2-yl)-4,5,6,7-tetrahydrobenzothiazole-2,6,7-triamine

2-amino-6-bromo-5,6-dihydrobenzothiazol-7(4H)-one

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