8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-bromophenyl)-, 2-fluoroethyl ester, (1R,2S,3S,5S)-

Base Information

Chemical Name:8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-bromophenyl)-, 2-fluoroethyl ester, (1R,2S,3S,5S)-
CAS No.:805255-30-5
Molecular Formula:C₁₆H₁₉BrFNO₂
Molecular Weight:356.235
Hs Code.:

Synonyms:

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Chemical Property of 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-bromophenyl)-, 2-fluoroethyl ester, (1R,2S,3S,5S)-

Chemical Property:

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Technology Process of 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-bromophenyl)-, 2-fluoroethyl ester, (1R,2S,3S,5S)-

There total 3 articles about 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-bromophenyl)-, 2-fluoroethyl ester, (1R,2S,3S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 805255-27-0
MCL 322

: 805255-30-5
(1R,2S,3S,5S)-3-(4-Bromo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 2-fluoro-ethyl ester

Guidance literature:: MCL 322; With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; for 48h; Heating;

With methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2004.08.049

Reference yield:

: 185348-32-7
(1R,2S,3S,5S)-3-(4-Bromo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carbonyl chloride

: 805255-30-5
(1R,2S,3S,5S)-3-(4-Bromo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 2-fluoro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂

2.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / 48 h / Heating

2.2: MeOH / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; triethylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2004.08.049

Reference yield:

: 135367-08-7
RTI 51

: 805255-30-5
(1R,2S,3S,5S)-3-(4-Bromo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 2-fluoro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / H₂O / dioxane / 24 h / Heating

2.1: POCl₃

3.1: Et₃N / CH₂Cl₂

4.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / 48 h / Heating

4.2: MeOH / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; water; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2004.08.049