2-Pyrrolidinone, 5-(2-hydroxyethyl)-, (5S)-

Base Information

Chemical Name:2-Pyrrolidinone, 5-(2-hydroxyethyl)-, (5S)-
CAS No.:808172-50-1
Molecular Formula:C₆H₁₁NO₂
Molecular Weight:129.159
Hs Code.:
DSSTox Substance ID:DTXSID60479071

Synonyms:808172-50-1;2-Pyrrolidinone, 5-(2-hydroxyethyl)-, (5S)-;(5S)-5-(2-HYDROXYETHYL)-2-PYRROLIDINONE;(5S)-5-(2-HYDROXYETHYL)PYRROLIDIN-2-ONE;(S)-5-(2-Hydroxyethyl)pyrrolidin-2-one;SCHEMBL157216;DTXSID60479071;MFCD19217591;AKOS006355030;AT10892;BS-36204

Suppliers and Price of 2-Pyrrolidinone, 5-(2-hydroxyethyl)-, (5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(5S)-5-(2-hydroxyethyl)-2-pyrrolidinone
10mg
$ 45.00

ChemBridge Corporation
(5S)-5-(2-hydroxyethyl)-2-pyrrolidinone 95%
1 g
$ 395.00

American Custom Chemicals Corporation
(5S)-5-(2-HYDROXYETHYL)-2-PYRROLIDINONE 95.00%
5MG
$ 459.90

AccelPharmtech
(5S)-5-(2-hydroxyethyl)-2-Pyrrolidinone 97.00%
25G
$ 7910.00

AccelPharmtech
(5S)-5-(2-hydroxyethyl)-2-Pyrrolidinone 97.00%
5G
$ 4220.00

AccelPharmtech
(5S)-5-(2-hydroxyethyl)-2-Pyrrolidinone 97.00%
1G
$ 2460.00

Total 2 raw suppliers

Chemical Property of 2-Pyrrolidinone, 5-(2-hydroxyethyl)-, (5S)-

Chemical Property:

PSA：52.82000
LogP:-0.07670
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:129.078978594
Heavy Atom Count:9
Complexity:114

Purity/Quality:

99% ^*data from raw suppliers

(5S)-5-(2-hydroxyethyl)-2-pyrrolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC1CCO
Isomeric SMILES:C1CC(=O)N[C@@H]1CCO

Technology Process of 2-Pyrrolidinone, 5-(2-hydroxyethyl)-, (5S)-

There total 21 articles about 2-Pyrrolidinone, 5-(2-hydroxyethyl)-, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124201-75-8,94157-93-4
(S)-(5-oxo-pyrrolidin-2-yl)-acetic acid ethyl ester

: 149427-84-9,808172-50-1
(S)-5-(2-hydroxy-ethyl)-pyrrolidin-2-one

Guidance literature:: With sodium tetrahydroborate; ethanol;
DOI:10.1002/cmdc.201800026

Reference yield: 93.0%

: 67036-44-6
methyl (S)-2-(5-oxopyrrolidin-2-yl)acetate

: 149427-84-9,808172-50-1
(S)-5-(2-hydroxy-ethyl)-pyrrolidin-2-one

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 4 - 20 ℃; for 3.25h;
DOI:10.1021/jo0524472

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 149427-84-9,808172-50-1
(S)-5-(2-hydroxy-ethyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / Et₃N / CH₂Cl₂

2: 95 percent / dimethylsulfoxide

3: 55 percent / H₂SO₄; H₂O

4: 90 percent / NaBH₄ / methanol

With sodium tetrahydroborate; sulfuric acid; water; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2007.02.008