4-Pyridinecarbonyl azide, 2,6-dichloro-

Base Information

• Chemical Name: 4-Pyridinecarbonyl azide, 2,6-dichloro-
• CAS No.: 81001-09-4
• Molecular Formula: C6H2Cl2N4O
• Molecular Weight: 217.014
• Mol file: 81001-09-4.mol

Synonyms:

Chemical Property of 4-Pyridinecarbonyl azide, 2,6-dichloro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarbonyl azide, 2,6-dichloro-

There total 1 articles about 4-Pyridinecarbonyl azide, 2,6-dichloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,6-dichloropyridine-4-carboxylic acid (5398-44-7) → 2,6-dichloropyridine-4-carbonylazide (81001-09-4)

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; In 1,4-dioxane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2021.113923

Reference yield:

2,6-dichloropyridine-4-carbonylazide (81001-09-4) → 2,6-dichloro-[4]pyridylamine (2587-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / benzene / 21 h / 90 °C

2: potassium carbonate / methanol / 7.5 h / 25 °C

With potassium carbonate; trifluoroacetic acid; In methanol; benzene; 1: |Curtius Rearrangement;

DOI:10.1002/cmdc.201300112

Reference yield:

2,6-dichloropyridine-4-carbonylazide (81001-09-4) → 6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile (1443830-80-5)

Guidance literature:

Multi-step reaction with 9 steps

1: trifluoroacetic acid / benzene / 21 h / 90 °C

2: potassium carbonate / methanol / 7.5 h / 25 °C

3: sulfuric acid; nitric acid / -5 °C

4: sulfuric acid / 1 h / 0 - 100 °C

5: 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C

6: acetonitrile / 5 h / 80 °C

7: tin(II) chloride dihdyrate / ethyl [2]alcohol / 3 h / 25 °C

8: toluene-4-sulfonic acid / 3 h / 120 °C

9: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium phosphate / toluene / 72 h / 90 °C / Inert atmosphere; Sealed tube

With potassium phosphate; tin(II) chloride dihdyrate; sulfuric acid; nitric acid; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; methanol; ethyl [2]alcohol; toluene; acetonitrile; benzene; 1: |Curtius Rearrangement;

DOI:10.1002/cmdc.201300112

upstream raw materials:

2,6-dichloropyridine-4-carboxylic acid

Downstream raw materials:

2,6-dichloro-4-isocyanatopyridine

6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

4-amino-6-chloro-3-nitropyridine-2-carbonitrile

2,6-dichloro-[4]pyridylamine