2-[(3-CHLOROPHENYL)METHOXYMETHYLENE]PROPANE DINITRILE

Base Information

• Chemical Name: 2-[(3-CHLOROPHENYL)METHOXYMETHYLENE]PROPANE DINITRILE
• CAS No.: 81066-92-4
• Molecular Formula: C₁₁H₇ClN₂O
• Molecular Weight: 218.642
• Mol file: 81066-92-4.mol

Synonyms:

Chemical Property of 2-[(3-CHLOROPHENYL)METHOXYMETHYLENE]PROPANE DINITRILE

Chemical Property:

• PSA: 56.81000
• LogP: 2.74466

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(3-CHLOROPHENYL)METHOXYMETHYLENE]PROPANE DINITRILE

There total 3 articles about 2-[(3-CHLOROPHENYL)METHOXYMETHYLENE]PROPANE DINITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H5ClN2O + dimethyl sulfate (77-78-1) → 2-[(3-Chloro-phenyl)-methoxy-methylene]-malononitrile (81066-92-4)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2019.07.048

Reference yield:

m-Chlorobenzoyl chloride (618-46-2) → 2-[(3-Chloro-phenyl)-methoxy-methylene]-malononitrile (81066-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 1.) 5-10 deg C, 2.) room temp., 1h

2: tetrahydrofuran / 2.5 h / Heating

With sodium hydride; In tetrahydrofuran;

DOI:10.1039/P19960001545

Reference yield:

dimethyl sulfate (77-78-1) + 2-(3-chlorobenzoyl)malononitrile → 2-[(3-Chloro-phenyl)-methoxy-methylene]-malononitrile (81066-92-4)

Guidance literature:

In tetrahydrofuran; for 2.5h; Heating;

DOI:10.1039/P19960001545

upstream raw materials:

dimethyl sulfate

m-Chlorobenzoyl chloride

Downstream raw materials:

2-Amino-4-(3-chloro-phenyl)-6-methoxy-pyrimidine-5-carbonitrile

2-Amino-4-(3-chloro-phenyl)-6-ethoxy-pyrimidine-5-carbonitrile

4-Amino-6-(3-chloro-phenyl)-2-methoxy-pyrimidine-5-carbonitrile

4-(3-Chloro-phenyl)-2-phenyl-6-thioxo-1,6-dihydro-pyrimidine-5-carbonitrile

Refernces

• 1、 Hanefeld, Ulf,Rees, Charles W.,White, Andrew J. P.,Williams, David J.. "One-pot synthesis of tetrasubstituted pyrazoles - Proof of regiochemistry". . p. 1545 - 1552. Retrieved 2007/10/03.