[4-(2-Iodoethoxy)-3-methoxyphenyl]methanol

Base Information

• Chemical Name: [4-(2-Iodoethoxy)-3-methoxyphenyl]methanol
• CAS No.: 81329-97-7
• Molecular Formula: C10H13IO3
• Molecular Weight: 308.116
• DSSTox Substance ID: DTXSID60531027
• Nikkaji Number: J1.634.188F
• Wikidata: Q82402567
• Mol file: 81329-97-7.mol

Synonyms:81329-97-7;[4-(2-iodoethoxy)-3-methoxyphenyl]methanol;SCHEMBL1888422;DTXSID60531027

Chemical Property of [4-(2-Iodoethoxy)-3-methoxyphenyl]methanol

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 307.99094
• Heavy Atom Count: 14
• Complexity: 154

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)CO)OCCI

Technology Process of [4-(2-Iodoethoxy)-3-methoxyphenyl]methanol

There total 3 articles about [4-(2-Iodoethoxy)-3-methoxyphenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(4-(2-bromoethoxy)-3-methoxyphenyl)methanol (98688-19-8) → [3-methyloxy-4-(2-iodoethoxy)phenyl]methanol (81329-97-7)

Guidance literature:

With sodium iodide; In acetone; at 50 ℃;

DOI:10.1021/ja0640501

Reference yield: 86.0%

→ [3-methyloxy-4-(2-iodoethoxy)phenyl]methanol (81329-97-7)

Guidance literature:

Reference yield:

4-hydroxymethyl-2-methoxyphenol (498-00-0) → [3-methyloxy-4-(2-iodoethoxy)phenyl]methanol (81329-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / aq. 12 N sodium hydroxide / ethanol / 5 h / Heating

2: 23 percent / sodium iodide / acetone / 8 h / Heating

With sodium hydroxide; sodium iodide; In ethanol; acetone;

DOI:10.1021/ja00310a041

upstream raw materials:

(4-(2-bromoethoxy)-3-methoxyphenyl)methanol

4-hydroxymethyl-2-methoxyphenol

Downstream raw materials:

2,7,12-tris<2-<4-(hydroxymethyl)-2-methoxyphenoxy>ethoxy>-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzocyclononene

2,7,12-tris<2-(4-hydroxymethyl-2-methoxyphenoxy)ethoxy>-3,8,13-trimetoxy-10,15-dihydro-5H-tribenzocyclononene

2,7,12-tris<2-(4-hydroxymethyl-2-methoxyphenoxy)ethoxy>-3,8,13-trimetoxy-10,15-dihydro-5H-tribenzocyclononene

2,7,12-tris<2-(4-hydroxymethyl-2-methoxyphenoxy)ethoxy>-3,8,13-trimetoxy-10,15-dihydro-5H-tribenzocyclononene