ethyl 2-amino-4-propyl-1,3-thiazole-5-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-4-propyl-1,3-thiazole-5-carboxylate
• CAS No.: 81569-37-1
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.288
• Mol file: 81569-37-1.mol

Synonyms:ethyl 2-amino-4-propyl-1,3-thiazol-5-carboxylate;amino-4-propyl-thiazole-5-carboxylic acid ethyl ester;2-amino-4-propyl-thiazole-5-carboxylic acid ethyl ester;ethyl 2-amino-4-propylthiazole-5-carboxylate;

Chemical Property of ethyl 2-amino-4-propyl-1,3-thiazole-5-carboxylate

Chemical Property:

• PSA: 93.45000
• LogP: 2.43570

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-amino-4-propyl-1,3-thiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-amino-4-propyl-1,3-thiazole-5-carboxylate

There total 7 articles about ethyl 2-amino-4-propyl-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-amino-2-thiocyanatohex-2-enoic acid ethyl ester → ethyl 2-amino-4-propylthiazole-5-carboxylate (81569-37-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 120h; Heating;

DOI:10.1016/S0040-4039(99)01235-6

Reference yield: 76.0%

ethyl butyroyl acetate (3249-68-1) + thiourea (17356-08-0) → ethyl 2-amino-4-propylthiazole-5-carboxylate (81569-37-1)

Guidance literature:

With erythrosine B; oxygen; In acetonitrile; at 20 ℃; for 10h; Irradiation; Green chemistry;

DOI:10.1002/adsc.201701565

Reference yield: 34.0%

ethyl 2-bromo-3-oxohexanoate (81569-68-8) + thiourea (17356-08-0) → ethyl 2-amino-4-propylthiazole-5-carboxylate (81569-37-1)

Guidance literature:

With triethylamine; In ethanol; for 16h;

upstream raw materials:

ethyl 2-bromo-3-oxohexanoate

thiourea

ethyl (2Z)-3-aminohex-2-enoate

ethyl 2-chloro-3-oxohexanoate

Downstream raw materials:

ethyl 2-fluoro-4-propylthiazole-5-carboxylate

ethyl-2-bromo-4-propyl-1,3-thiazol-5-carboxylate

4-propylthiazole-5-carboxylic acid

2-bromo-4-propylthiazole-5-carboxylic acid