6-Chloro-3-methyl-1-benzofuran-2-carboxylic acid

Base Information

Chemical Name:6-Chloro-3-methyl-1-benzofuran-2-carboxylic acid
CAS No.:81718-75-4
Molecular Formula:C₁₀H₇ClO₃
Molecular Weight:210.617
Hs Code.:
European Community (EC) Number:877-797-4
ChEMBL ID:CHEMBL2314506

Synonyms:CHEMBL2314506;6-chloro-3-methyl-1-benzofuran-2-carboxylic acid;81718-75-4;SCHEMBL1385653;BDBM50424780;EN300-23925581;Z1416191044

Suppliers and Price of 6-Chloro-3-methyl-1-benzofuran-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Chloro-3-methyl-1-benzofuran-2-carboxylic acid

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:210.0083718
Heavy Atom Count:14
Complexity:244

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(OC2=C1C=CC(=C2)Cl)C(=O)O

Technology Process of 6-Chloro-3-methyl-1-benzofuran-2-carboxylic acid

There total 1 articles about 6-Chloro-3-methyl-1-benzofuran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 30335-94-5
(2-acetyl-5-chlorophenoxy)acetic acid ethyl ester

: 30343-35-2
3-methyl-6-chlorobenzofuran

: 30335-95-6
(2-acetyl-5-chlorophenoxy)acetic acid

: 77956-72-0
8-Chloro-benzo[b]oxepine-3,5-dione

: 81718-75-4
6-Chloro-3-methyl-benzofuran-2-carboxylic acid

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; at 60 ℃; for 6h;

Reference yield:

: 125074-46-6,31246-62-5,31246-63-6,31246-66-9,53261-25-9
(OC-6-33)-(diammine)dichloridodihydroxidoplatinum(IV)

: 81718-75-4
6-Chloro-3-methyl-benzofuran-2-carboxylic acid

: C₂₀H₁₈Cl₄N₂O₆Pt

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 72h;

Reference yield:

: 81718-75-4
6-Chloro-3-methyl-benzofuran-2-carboxylic acid

: 6-chloro-N-(2-iodophenyl)-N,3-dimethylbenzofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jacs.8b09186