2-AMINOFLUBENDAZOLE

Base Information

• Chemical Name: 2-AMINOFLUBENDAZOLE
• CAS No.: 82050-13-3
• Molecular Formula: C₁₄H₁₀FN₃O
• Molecular Weight: 255.251
• Mol file: 82050-13-3.mol

Synonyms:(2-Amino-1H-benzoimidazol-5-yl)-(4-fluoro-phenyl)-methanone;2-Amino-5-(4-fluorobenzoyl)-1H-benzimidazole;2-Aminoflubendazole;Methanone,(2-amino-1H-benzimidazol-5-yl)(4-fluorophenyl);Hydrolyzed flubendazole;

Chemical Property of 2-AMINOFLUBENDAZOLE

Chemical Property:

• Melting Point: approximate 249℃ (dec.)
• PSA: 72.50000
• LogP: 2.44530
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%Min ^*data from raw suppliers

(2-Amino-1H-benzimidazol-6-yl)(4-fluorophenyl)-methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 8849496
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The hydrolyzed form of Flubendazole (F418500), which is an anthelmintic.

Technology Process of 2-AMINOFLUBENDAZOLE

There total 1 articles about 2-AMINOFLUBENDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate (31430-15-6) → 6-(4-fluorobenzoyl)-1H-benzimidazol-2-amine (82050-13-3)

Guidance literature:

With hydrogen bromide; for 19h; Reflux;

DOI:10.2174/15701808113109990028

Reference yield: 49.0%

6-(4-fluorobenzoyl)-1H-benzimidazol-2-amine (82050-13-3) + (+/-)-1-(carboxymethyl)-3-<(tert-butoxycarbonyl)amino>-2-piperidone (733049-29-1) → 2-(3-tert-butoxycarbonylamino-2-oxopiperidin-1-yl)-N-(5-(4-fluorobenzoyl)-3H-benzimidazol-2-yl)acetamide

Guidance literature:

(+/-)-1-(carboxymethyl)-3-<(tert-butoxycarbonyl)amino>-2-piperidone; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

6-(4-fluorobenzoyl)-1H-benzimidazol-2-amine; With triethylamine; In dichloromethane; water; at 20 ℃; for 20h;

DOI:10.2174/15701808113109990028

upstream raw materials:

methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate