5H-Pyrrolo(3,2-d)pyrimidin-4-amine, 2-chloro-N-(2-cyclohexylethyl)-

Base Information

Chemical Name:5H-Pyrrolo(3,2-d)pyrimidin-4-amine, 2-chloro-N-(2-cyclohexylethyl)-
CAS No.:114685-00-6
Molecular Formula:C14H19 Cl N4
Molecular Weight:278.7805
Hs Code.:
DSSTox Substance ID:DTXSID20150819
Wikidata:Q83017022

Synonyms:BRN 5565075;5H-Pyrrolo(3,2-d)pyrimidin-4-amine, 2-chloro-N-(2-cyclohexylethyl)-;114685-00-6;2-Chloro-N-(2-cyclohexylethyl)-5H-pyrrolo(3,2-d)pyrimidin-4-amine;C14H19ClN4;C14-H19-Cl-N4;DTXSID20150819;LS-139515

Suppliers and Price of 5H-Pyrrolo(3,2-d)pyrimidin-4-amine, 2-chloro-N-(2-cyclohexylethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5H-Pyrrolo(3,2-d)pyrimidin-4-amine, 2-chloro-N-(2-cyclohexylethyl)-

Chemical Property:

Vapor Pressure:3.35E-08mmHg at 25°C
Boiling Point:447.5°Cat760mmHg
Flash Point:224.4°C
Density:1.274g/cm³
XLogP3:4.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:278.1298243
Heavy Atom Count:19
Complexity:283

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)CCNC2=NC(=NC3=C2NC=C3)Cl

Technology Process of 5H-Pyrrolo(3,2-d)pyrimidin-4-amine, 2-chloro-N-(2-cyclohexylethyl)-

There total 5 articles about 5H-Pyrrolo(3,2-d)pyrimidin-4-amine, 2-chloro-N-(2-cyclohexylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

: 4442-85-7
2-cyclohexylethylamine

: 63200-54-4
2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine

: 114685-00-6
(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-(2-cyclohexyl-ethyl)-amine

Guidance literature:: With potassium carbonate; In ethanol; for 7h; Heating;
DOI:10.1007/BF00758443

Reference yield:

: 16632-21-6
5-nitro-6-methyluracil

: 114685-00-6
(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-(2-cyclohexyl-ethyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C

2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C

3: 60.6 percent / POCl₃ / 6 h / Heating

4: 18 percent / POCl₃, diethylaniline / 40 h / Heating

5: 85.6 percent / potassium carbonate / aq. ethanol / 7 h / Heating

With potassium carbonate; acetic acid; N,N-diethylaniline; zinc; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/BF00758443

Reference yield:

: 65996-50-1
2,4-Dioxo-1,2,3,4-tetrahydropyrrolo<3,2-d>pyrimidine

: 114685-00-6
(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-(2-cyclohexyl-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 60.6 percent / POCl₃ / 6 h / Heating

2: 18 percent / POCl₃, diethylaniline / 40 h / Heating

3: 85.6 percent / potassium carbonate / aq. ethanol / 7 h / Heating

With potassium carbonate; N,N-diethylaniline; trichlorophosphate; In ethanol;
DOI:10.1007/BF00758443