Diethyl [bromo(difluoro)methyl](phenyl)propanedioate

Base Information

Chemical Name:Diethyl [bromo(difluoro)methyl](phenyl)propanedioate
CAS No.:82477-48-3
Molecular Formula:C14H15BrF2O4
Molecular Weight:365.172
Hs Code.:
DSSTox Substance ID:DTXSID70513379
Wikidata:Q82373166

Synonyms:82477-48-3;Diethyl [bromo(difluoro)methyl](phenyl)propanedioate;DTXSID70513379

Suppliers and Price of Diethyl [bromo(difluoro)methyl](phenyl)propanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Diethyl [bromo(difluoro)methyl](phenyl)propanedioate

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:364.01218
Heavy Atom Count:21
Complexity:363

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C1=CC=CC=C1)(C(=O)OCC)C(F)(F)Br

Technology Process of Diethyl [bromo(difluoro)methyl](phenyl)propanedioate

There total 2 articles about Diethyl [bromo(difluoro)methyl](phenyl)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 75-61-6
dibromodifluoromethane

: 83-13-6
diethyl 2-phenylmalonate

: 791-25-3
diethyl 2-(difluoromethyl)-2-phenylmalonate

: 82477-48-3
diethyl α-bromodifluoromethyl-α-phenylmalonate

Guidance literature:: With sodium hydride; In tetrahydrofuran; Yields of byproduct given; 1.) room temperature -> 0 deg C, 2.) 0 deg C -> room temperature, 2 h;

Reference yield:

: 75-61-6
dibromodifluoromethane

: 83-13-6
diethyl 2-phenylmalonate

: 82477-48-3
diethyl α-bromodifluoromethyl-α-phenylmalonate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1) THF, 0.5 h, 2) room temperature, 10 days;
DOI:10.1016/S0040-4039(01)80149-0

Reference yield: 42.0%

: 82477-48-3
diethyl α-bromodifluoromethyl-α-phenylmalonate

: 90784-42-2
ethyl 3,3,3-trifluoro-2-phenylpropionate

Guidance literature:: With potassium fluoride; In dimethyl sulfoxide; at 170 ℃; for 2h;
DOI:10.1016/S0040-4039(01)80149-0 DOI:10.1021/jo00194a006