Methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Base Information

Chemical Name:Methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate
CAS No.:82483-66-7
Molecular Formula:C₇H₉NO₃
Molecular Weight:155.153
Hs Code.:
DSSTox Substance ID:DTXSID201218937
Nikkaji Number:J2.585.008D
Mol file:82483-66-7.mol

Synonyms:82483-66-7;Methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate;DTXSID201218937;3-Formyl-2-pyrroline-1-carboxylic acid methyl ester;1H-Pyrrole-1-carboxylic acid,4-formyl-2,3-dihydro-,methyl ester(9ci)

Suppliers and Price of Methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Chemical Property:

PSA：46.61000
LogP:0.47920
XLogP3:-0.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:155.058243149
Heavy Atom Count:11
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)N1CCC(=C1)C=O

Technology Process of Methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate

There total 3 articles about Methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 76460-88-3
N-methoxycarbonyl-2,3-dihydropyrrole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 82483-66-7
methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With trichlorophosphate; In 1,2-dichloro-ethane; at 0 - 5 ℃;
DOI:10.1016/S0040-4039(00)87059-8

Reference yield:

: 56475-88-8
methyl 2-methoxypyrrolidine-1-carboxylate

: 82483-66-7
methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NH₄Cl / 3 h / 20 - 100 Torr / Heating

2: 1.) POCl₃, 2.) AcONa / 1.) ethylene dichloride, 0-5 deg C, 1 h -> reflux, 15 min, 2.) H₂O, reflux, 15 min

With sodium acetate; ammonium chloride; trichlorophosphate;
DOI:10.1021/ja00388a037

Reference yield:

: 56475-80-0
N-(methoxycarbonyl)pyrrolidine

: 82483-66-7
methyl 4-formyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: anodic oxidation in tetraethylammonium p-toluenesulfonate

2: 91 percent / NH₄Cl / 3 h / 20 - 100 Torr / Heating

3: 1.) POCl₃, 2.) AcONa / 1.) ethylene dichloride, 0-5 deg C, 1 h -> reflux, 15 min, 2.) H₂O, reflux, 15 min

With sodium acetate; ammonium chloride; trichlorophosphate;
DOI:10.1021/ja00388a037