4-methyl-2,2-diphenyltetrahydrofuran

Base Information

• Chemical Name: 4-methyl-2,2-diphenyltetrahydrofuran
• CAS No.: 82668-86-8
• Molecular Formula: C17H18O
• Molecular Weight: 238.329
• Mol file: 82668-86-8.mol

Synonyms:4-methyl-2,2-diphenyltetrahydrofuran;3-methyl-5-diphenyldihydrofuran;4-Methyl-2,2-diphenyl-tetrahydro-furan;

Chemical Property of 4-methyl-2,2-diphenyltetrahydrofuran

Chemical Property:

• Melting Point: 47 - 48 °C
• PSA: 9.23000
• LogP: 3.98660

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-2,2-diphenyltetrahydrofuran

There total 4 articles about 4-methyl-2,2-diphenyltetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(2-bromo-1,1-diphenylethoxy)propene (74249-43-7) → 2,2-diphenyl-4-methyltetrahydrofuran (82668-86-8)

Guidance literature:

With tri-n-butyl-tin hydride; indium(III) chloride; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(01)00816-4

Reference yield: 44.0%

3-(2-bromo-1,1-diphenylethoxy)propene (74249-43-7) → 2,2-diphenyl-4-methyltetrahydrofuran (82668-86-8) + C34H34O2

Guidance literature:

With ammonium perchlorate; (η⁴-5,7,7,11,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane)nickel(II) perchlorate; tetraethylammonium perchlorate; In N,N-dimethyl-formamide; for 5h; Product distribution; Mechanism; electrolysis; var. nickel(II) complexes; other halogeno ethers; reduction with var. metals;

DOI:10.1039/c39920001120

Reference yield:

1,1-Diphenylethylene (530-48-3) → 2,2-diphenyl-4-methyltetrahydrofuran (82668-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dichloromethane / -30 - 15 °C / Inert atmosphere; Schlenk technique

2: iron(II) chloride; sodium tetrahydroborate / acetonitrile / 16 h / 50 °C / Inert atmosphere; Sealed tube; Glovebox

With sodium tetrahydroborate; N-Bromosuccinimide; iron(II) chloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2016.08.039

upstream raw materials:

3-(2-bromo-1,1-diphenylethoxy)propene

1,2-dibromo-1,1-diphenylethane

1,1-Diphenylethylene