5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

• Chemical Name: 5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• CAS No.: 82703-33-1
• Molecular Formula: C8H10N4
• Molecular Weight: 162.194
• European Community (EC) Number: 838-364-5
• ChEMBL ID: CHEMBL93867
• Nikkaji Number: J347.498D
• Mol file: 82703-33-1.mol

Synonyms:5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;82703-33-1;CHEMBL93867;BDBM50014277;AKOS009159523;SB18560;CS-0056852;EN300-71445;P10152;5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine;Z385405912

Chemical Property of 5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Chemical Property:

• Melting Point: 281 °C (ethanol)
• PSA: 67.59000
• LogP: 1.73810
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 162.090546336
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(NC2=NC=NC(=C12)N)C

Technology Process of 5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 11 articles about 5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5,6-Dimethyl-7-(DL-1-phenylethyl)-7H-pyrrolo<2,3-d>pyrimidin-4-amin (82703-43-3) → 4-amino-5,6-dimethyl-7(H)-pyrrolo<2,3-d>pyrimidine (82703-33-1)

Guidance literature:

With aluminum (III) chloride; In toluene; for 3h; Reflux;

Reference yield: 53.6%

5,6-Dimethyl-7-(DL-1-phenylethyl)-7H-pyrrolo<2,3-d>pyrimidin-4-amin (82703-43-3) → styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 4-amino-5,6-dimethyl-7(H)-pyrrolo<2,3-d>pyrimidine (82703-33-1)

Guidance literature:

With PPA; at 60 ℃; for 1.5h;

Reference yield: 53.6%

4-(Diacetylamino)-5,6-dimethyl-7-(DL-1-phenylethyl)-7H-pyrrolo<2,3-d>pyrimidin (103026-38-6) → styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 4-amino-5,6-dimethyl-7(H)-pyrrolo<2,3-d>pyrimidine (82703-33-1)

Guidance literature:

With PPA; at 60 ℃; for 1.5h;

upstream raw materials:

7-Cyclopentyl-5,6-dimethyl-7H-pyrrolo<2,3-d>pyrimidin-4-amin

5,6-Dimethyl-7-(2-thienylmethyl)-7H-pyrrolo<2,3-d>pyrimidin-4-amin

5,6-Dimethyl-7-(DL-1-phenylethyl)-7H-pyrrolo<2,3-d>pyrimidin-4-amin

4-(Diacetylamino)-5,6-dimethyl-7-(DL-1-phenylethyl)-7H-pyrrolo<2,3-d>pyrimidin

Downstream raw materials:

7-<2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-d-erythropentofuranosyl>-5,6-dimethylpyrrolo<2,3-d>pyrimidin-4-amine