2,4-Bis(6-bromo-1H-indol-3-yl)-1H-imidazole

Base Information

Chemical Name:2,4-Bis(6-bromo-1H-indol-3-yl)-1H-imidazole
CAS No.:134029-43-9
Molecular Formula:C19H12Br2N4
Molecular Weight:0
Hs Code.:
Mol file:134029-43-9.mol

Synonyms:3,3'-Imidazole-2,4-diylbis(6-bromoindole);Nortopsentin A;3,3'-(1H-imidazole-2,5-diyl)bis(6-bromo-1H-indole);

Suppliers and Price of 2,4-Bis(6-bromo-1H-indol-3-yl)-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 2,4-Bis(6-bromo-1H-indol-3-yl)-1H-imidazole

Chemical Property:

PSA：60.26000
LogP:6.23130

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,4-Bis(6-bromo-1H-indol-3-yl)-1H-imidazole

There total 8 articles about 2,4-Bis(6-bromo-1H-indol-3-yl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: C₃₃H₂₄Br₂N₄O₄S₂

: 134029-43-9
nortopsentin A

Guidance literature:: With naphthalene; sodium; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/acs.jafc.8b00507

Reference yield:

: 52415-29-9
6-bromo-1H-indole

: 134029-43-9
nortopsentin A

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / acetonitrile / 0.17 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 2 h / 0 - 20 °C

3.1: copper(ll) bromide / ethyl acetate / 5 h / Reflux

4.1: potassium hydrogencarbonate / tetrahydrofuran; water / 4 h / Reflux

5.1: sodium; naphthalene / tetrahydrofuran / 2 h / -78 °C

With aluminum (III) chloride; naphthalene; sodium; sodium hydride; potassium hydrogencarbonate; copper(ll) bromide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/acs.jafc.8b00507

Reference yield:

: N-tosyl-3-cyano-6-bromoindole

: 134029-43-9
nortopsentin A

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 5 h / Reflux

2: hydrogen; acetic acid / methanol / 12 h / 20 °C

3: potassium hydrogencarbonate / tetrahydrofuran; water / 4 h / Reflux

4: sodium; naphthalene / tetrahydrofuran / 2 h / -78 °C

With naphthalene; hydroxylamine hydrochloride; hydrogen; sodium; sodium hydrogencarbonate; potassium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1021/acs.jafc.8b00507