5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid

Base Information

Chemical Name:5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
CAS No.:4906-68-7
Molecular Formula:C13H9 Br O3
Molecular Weight:293.1128
Hs Code.:
NSC Number:109116
DSSTox Substance ID:DTXSID70296397
Wikidata:Q82036989
Pharos Ligand ID:N4FRXXK2YWT5
ChEMBL ID:CHEMBL387536
Mol file:4906-68-7.mol

Synonyms:4906-68-7;AKR1C1-IN-1;3-bromo-2-hydroxy-5-phenylbenzoic acid;5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;3-bromo-5-phenylsalicylic acid;3-Bromo-5-phenyl salicylic acid;NSC-109116;CHEMBL387536;5-bromo-4-hydroxybiphenyl-3-carboxylic acid;5-BROMO-4-HYDROXY-(1,1'-BIPHENYL)-3-CARBOXYLIC ACID;3-Bromo-5-phenylsalicylc acid;3-bromo-5-phenylsalicyclic acid;NSC109116;SCHEMBL18319714;DTXSID70296397;XVZSXNULHSIRCQ-UHFFFAOYSA-N;BDBM50219490;AKOS005151372;LG-0054;HY-114009;CS-0064859;S0764;E76500;5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylicacid

Suppliers and Price of 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

CSNpharm
3-bromo-5-phenylSalicylicAcid
50mg
$ 540.00

CSNpharm
3-bromo-5-phenylSalicylicAcid
10mg
$ 180.00

CSNpharm
3-bromo-5-phenylSalicylicAcid
1mg
$ 68.00

Cayman Chemical
3-bromo-5-phenyl Salicylic Acid ≥95%
1mg
$ 51.00

Cayman Chemical
3-bromo-5-phenyl Salicylic Acid ≥95%
5mg
$ 230.00

Cayman Chemical
3-bromo-5-phenyl Salicylic Acid ≥95%
25mg
$ 893.00

Cayman Chemical
3-bromo-5-phenyl Salicylic Acid ≥95%
10mg
$ 408.00

ApexBio Technology
3-bromo-5-phenylSalicylicAcid
5mg
$ 319.00

ApexBio Technology
3-bromo-5-phenylSalicylicAcid
10mg
$ 566.00

ApexBio Technology
3-bromo-5-phenylSalicylicAcid
25mg
$ 1238.00

Total 8 raw suppliers

Chemical Property of 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid

Chemical Property:

Vapor Pressure:3.7E-07mmHg at 25°C
Boiling Point:401.2°Cat760mmHg
Flash Point:196.4°C
PSA：57.53000
Density:1.611g/cm³
LogP:3.51990
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:291.97351
Heavy Atom Count:17
Complexity:276

Purity/Quality:

97% ^*data from raw suppliers

3-bromo-5-phenylSalicylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC(=C(C(=C2)Br)O)C(=O)O
Description The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).

Technology Process of 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid

There total 3 articles about 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%