Technology Process of 8-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine
There total 3 articles about 8-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
acetic acid;
at 50 - 60 ℃;
DOI:10.1248/cpb.32.2522
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 37 percent / Et3N, piperidinium acetate / 24 h / 120 °C
2: 1.) LDA / 1.) THF, 1 h, -68 deg C; 2.) THF, 15 min, -55 deg C
3: 92 percent / H2 / Pd-C / acetic acid / 50 - 60 °C
With
hydrogen; piperdinium acetate; triethylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
acetic acid;
DOI:10.1248/cpb.32.2522
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) LDA / 1.) THF, 1 h, -68 deg C; 2.) THF, 15 min, -55 deg C
2: 92 percent / H2 / Pd-C / acetic acid / 50 - 60 °C
With
hydrogen; lithium diisopropyl amide;
palladium on activated charcoal;
In
acetic acid;
DOI:10.1248/cpb.32.2522