1-(2-Methylphenyl)-3-azabicyclo[3.1.0]hexane

Base Information

Chemical Name:1-(2-Methylphenyl)-3-azabicyclo[3.1.0]hexane
CAS No.:83177-53-1
Molecular Formula:C12H15N
Molecular Weight:173.258
Hs Code.:
ChEMBL ID:CHEMBL1193850
DSSTox Substance ID:DTXSID70507975

Synonyms:1-(2-methylphenyl)-3-azabicyclo[3.1.0]hexane;83177-53-1;SCHEMBL3477065;CHEMBL1193850;DTXSID70507975;1-tolyl-3-azabicyclo-[3.1.0]hexane;1-(o-Tolyl)-3-azabicyclo[3.1.0]hexane;CS-0456058

Suppliers and Price of 1-(2-Methylphenyl)-3-azabicyclo[3.1.0]hexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-(2-Methylphenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:173.120449483
Heavy Atom Count:13
Complexity:213

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1C23CC2CNC3

Technology Process of 1-(2-Methylphenyl)-3-azabicyclo[3.1.0]hexane

There total 6 articles about 1-(2-Methylphenyl)-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 77053-88-4
1-o-Tolyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione

: 83177-53-1
1-(2-methylphenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; for 2h; Heating;
DOI:10.1021/jm00137a002

Reference yield:

: 129592-87-6,77053-54-4
methyl 2-bromo-2-(2-methylphenyl)acetate

: 83177-53-1
1-(2-methylphenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

2: 33 percent / KOH / ethanol; H₂O / 6 h / Heating

3: 22 percent / urea / xylene / Heating

4: 42 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating

With potassium hydroxide; sodium methylate; sodium bis(2-methoxyethoxy)aluminium dihydride; urea; In diethyl ether; ethanol; water; xylene; benzene;
DOI:10.1021/jm00137a002

Reference yield:

: 77062-83-0,1011722-47-6
methyl 2-hydroxy-2-(o-tolyl)acetate

: 83177-53-1
1-(2-methylphenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / PBr₃ / CHCl₃

2: 67 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

3: 33 percent / KOH / ethanol; H₂O / 6 h / Heating

4: 22 percent / urea / xylene / Heating

5: 42 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating

With potassium hydroxide; sodium methylate; phosphorus tribromide; sodium bis(2-methoxyethoxy)aluminium dihydride; urea; In diethyl ether; ethanol; chloroform; water; xylene; benzene;
DOI:10.1021/jm00137a002