1-(3-Methoxyphenyl)-3-azabicyclo[3.1.0]hexane

Base Information

• Chemical Name: 1-(3-Methoxyphenyl)-3-azabicyclo[3.1.0]hexane
• CAS No.: 83177-57-5
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• ChEMBL ID: CHEMBL1192245
• DSSTox Substance ID: DTXSID90507977
• Mol file: 83177-57-5.mol

Synonyms:1-(3-methoxyphenyl)-3-azabicyclo[3.1.0]hexane;83177-57-5;starbld0019099;SCHEMBL378266;CHEMBL1192245;DTXSID90507977

Chemical Property of 1-(3-Methoxyphenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 189.115364102
• Heavy Atom Count: 14
• Complexity: 230

Purity/Quality:

≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C23CC2CNC3

Technology Process of 1-(3-Methoxyphenyl)-3-azabicyclo[3.1.0]hexane

There total 7 articles about 1-(3-Methoxyphenyl)-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

1-(m-methoxyphenyl)-1,2-cyclopropanedicarboximide (66505-06-4) → 1-(3-methoxyphenyl)-3-azabicyclo[3.1.0]hexane (83177-57-5)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; for 2h; Heating;

DOI:10.1021/jm00137a002

Reference yield:

methyl 2-hydroxy-2-(3-methoxyphenyl)acetate (54845-40-8) → 1-(3-methoxyphenyl)-3-azabicyclo[3.1.0]hexane (83177-57-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 40 percent / PBr₃ / CHCl₃

2: 25 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

3: KOH / ethanol; H₂O / 6 h / Heating

4: 40 percent / urea / xylene / Heating

5: 24 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating

With potassium hydroxide; sodium methylate; phosphorus tribromide; sodium bis(2-methoxyethoxy)aluminium dihydride; urea; In diethyl ether; ethanol; chloroform; water; xylene; benzene;

DOI:10.1021/jm00137a002

Reference yield:

bromo-(3-methoxy-phenyl)-acetic acid methyl ester (86215-57-8) → 1-(3-methoxyphenyl)-3-azabicyclo[3.1.0]hexane (83177-57-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 25 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

2: KOH / ethanol; H₂O / 6 h / Heating

3: 40 percent / urea / xylene / Heating

4: 24 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating

With potassium hydroxide; sodium methylate; sodium bis(2-methoxyethoxy)aluminium dihydride; urea; In diethyl ether; ethanol; water; xylene; benzene;

DOI:10.1021/jm00137a002

upstream raw materials:

1-(m-methoxyphenyl)-1,2-cyclopropanedicarboximide

methyl 2-hydroxy-2-(3-methoxyphenyl)acetate

bromo-(3-methoxy-phenyl)-acetic acid methyl ester

(1R,2S)-1-(3-Methoxy-phenyl)-cyclopropane-1,2-dicarboxylic acid

Downstream raw materials:

1-(m-methoxyphenyl)-3-methyl-3-azabicyclo[3.1.0]hexane

Refernces