3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid

Base Information

Chemical Name:3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid
CAS No.:83249-08-5
Molecular Formula:C₆H₈O₃
Molecular Weight:128.128
Hs Code.:
European Community (EC) Number:873-406-6
Nikkaji Number:J1.740.615I

Synonyms:3-hydroxybicyclo[1.1.1]pentane-1-carboxylic acid;83249-08-5;Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-hydroxy-;MFCD19230741;SCHEMBL16038181;AKOS006386430;SB16266;AS-53483;SY046670;CS-0051338;EN300-113972;P16565;3-hydroxybicyclo[1.1.1]pentane-1-carboxylicacid;EN300-37374044

Suppliers and Price of 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 8 raw suppliers

Chemical Property of 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid

Chemical Property:

XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:128.047344113
Heavy Atom Count:9
Complexity:165

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2(CC1(C2)O)C(=O)O

Technology Process of 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid

There total 3 articles about 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: benzyl 3-hydroxybicyclo[1.1.1]pentane-1-carboxylate

: 83249-08-5
3-hydroxybicyclo<1.1.1>pentane-1-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;
DOI:10.1021/acs.joc.1c00977

Reference yield: 52.0%

: 83249-06-3
3-acetoxy-1-phenylbicyclo<1.1.1>pentane

: 83249-08-5
3-hydroxybicyclo<1.1.1>pentane-1-carboxylic acid

: 83249-07-4
3-acetoxybicyclo<1.1.1>pentane-1-carboxylic acid

Guidance literature:: With ruthenium(IV) oxide; sodium hypochlorite; In tetrachloromethane; for 48h;
DOI:10.1021/jo00146a031

Reference yield:

: potassium (3-((benzyloxy)carbonyl)bicyclo[1.1.1]pentan-1-yl)trifluoroborate

: 83249-08-5
3-hydroxybicyclo<1.1.1>pentane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium dihydrogenphosphate; dihydrogen peroxide / water; tetrahydrofuran / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With potassium dihydrogenphosphate; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/acs.joc.1c00977