16-fluoroestradiol

Base Information

Chemical Name:16-fluoroestradiol
CAS No.:84693-92-5
Molecular Formula:C₁₈H₂₃FO₂
Molecular Weight:290.378
Hs Code.:
Mol file:84693-92-5.mol

Synonyms:16b-Fluoro-1,3,5(10)-estratriene-3,17b-diol; 16b-Fluoroestradiol

Suppliers and Price of 16-fluoroestradiol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 16-fluoroestradiol

Chemical Property:

Vapor Pressure:5.12E-09mmHg at 25°C
Melting Point:225 - 227 °C
Boiling Point:453.6°C at 760 mmHg
Flash Point:228.1°C
PSA：40.46000
Density:1.24g/cm³
LogP:3.55720

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 16-fluoroestradiol

There total 10 articles about 16-fluoroestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 92817-03-3
16β-Fluoro-3-<<(trifluoromethyl)sulfonyl>oxy>estra-1,3,5(10)-trien-17-one

: 84693-92-5
16beta-Fluoroestradiol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -78 - 20 ℃; for 0.216667h;
DOI:10.1021/jm00063a012

Reference yield: 80.0%

: 2249-40-3
3-acetoxy-16β-fluoro-estra-1,3,5(10)-trien-17-one

: 84693-92-5
16beta-Fluoroestradiol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 4 ℃; for 24h;
DOI:10.1021/jo00155a015

Reference yield:

: 566-76-7
16α-hydroxyestrone

: 84693-92-5
16beta-Fluoroestradiol

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

3: 86 percent / LiAlH₄ / diethyl ether / 0.22 h / -78 - 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00063a012