4,1-Benzoxazepin-2(3H)-one, 7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphen yl)-1-(2,2-dimethylpropyl)-1,5-dihydro-, (3R,5S)-

Base Information

Chemical Name:4,1-Benzoxazepin-2(3H)-one, 7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphen yl)-1-(2,2-dimethylpropyl)-1,5-dihydro-, (3R,5S)-
CAS No.:839725-16-5
Molecular Formula:C25H27Cl2N3O4S
Molecular Weight:536.479
Hs Code.:

4,1-Benzoxazepin-2(3H)-one,
7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphen
yl)-1-(2,2-dimethylpropyl)-1,5-dihydro-, (3R,5S)-

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Chemical Property of 4,1-Benzoxazepin-2(3H)-one, 7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphen yl)-1-(2,2-dimethylpropyl)-1,5-dihydro-, (3R,5S)-

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Technology Process of 4,1-Benzoxazepin-2(3H)-one, 7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphen yl)-1-(2,2-dimethylpropyl)-1,5-dihydro-, (3R,5S)-

There total 1 articles about 4,1-Benzoxazepin-2(3H)-one, 7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphen yl)-1-(2,2-dimethylpropyl)-1,5-dihydro-, (3R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 839725-24-5
2-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]ethanethioamide

: 75-70-7
trichloromethyl mercaptan

: 839725-16-5
(3R,5S)-7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

Guidance literature:: 2-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]ethanethioamide; With methyl iodide; In acetone; for 14h;

With ammonium acetate; In methanol; for 4h; Heating / reflux;

trichloromethyl mercaptan; With sodium hydroxide; more than 3 stages;

Reference yield: 90.0%

: 839725-16-5
(3R,5S)-7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

: 623-51-8
ethyl 2-sulfanylacetate

: ethyl [(3-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]methyl}-1,2,4-thiadiazol-5-yl)thio]acetate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 45 ℃; for 16h;

Reference yield:

: 839725-16-5
(3R,5S)-7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

: 5466-06-8
3-mercaptopropionic acid ethyl ester

: C₃₀H₃₆ClN₃O₆S₂

Guidance literature:: (3R,5S)-7-chloro-3-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-1,5-dihydro-4,1-benzoxazepin-2(3H)-one; 3-mercaptopropionic acid ethyl ester; With potassium carbonate; In tetrahydrofuran; at 45 ℃; for 13.5h;

for 1h;