Daidzein

Base Information Edit

Chemical Name:Daidzein
CAS No.:486-66-8
Molecular Formula:C15H10O4
Molecular Weight:254.242
Hs Code.:DERIVATION
European Community (EC) Number:207-635-4
UNII:6287WC5J2L
ChEMBL ID:CHEMBL8145
DSSTox Substance ID:DTXSID9022310
Metabolomics Workbench ID:22176
NCI Thesaurus Code:C1060
Nikkaji Number:J6.014C
Pharos Ligand ID:4BPRLSR2SX4Z
Wikidata:Q408732
Wikipedia:Daidzein
Mol file:486-66-8.mol

Synonyms:daidzein;diadzein

Suppliers and Price of Daidzein

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Daidzein
20mg
$ 255.00

Usbiological
Daidzein
50mg
$ 353.00

Usbiological
Daidzein
500mg
$ 326.00

Usbiological
Daidzein
1g
$ 189.00

TRC
Daidzein
25mg
$ 45.00

Tocris
Daidzein ≥99%(HPLC)
50
$ 115.00

TCI Chemical
Daidzein >98.0%(HPLC)(T)
1g
$ 155.00

SynQuest Laboratories
7-Hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 97.0%
1 g
$ 226.00

SynQuest Laboratories
7-Hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 97.0%
250 mg
$ 106.00

SynQuest Laboratories
7-Hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 97.0%
100 mg
$ 65.00

Total 235 raw suppliers

Chemical Property of Daidzein Edit

Chemical Property:

Appearance/Colour:off-white crystalline powder
Vapor Pressure:4.53E-10mmHg at 25°C
Melting Point:315-323 °C (dec.)
Refractive Index:1.698
Boiling Point:512.8 °C at 760 mmHg
PKA:7.01±0.20(Predicted)
Flash Point:201.2 °C
PSA：70.67000
Density:1.443 g/cm³
LogP:2.87120
Storage Temp.:2-8°C
Solubility.:DMSO: 10 mg/mL
Water Solubility.:insoluble
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:254.05790880
Heavy Atom Count:19
Complexity:382

Purity/Quality:

NLT 98% ^*data from raw suppliers

Daidzein ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/38
Safety Statements: 24-26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O
Recent ClinicalTrials:The Effects of Soy Isoflavones to Improve the Metabolism of Glucose and Lipids
Description Daidzein mainly comes from leguminous plants, the seeds of soybean (dadou), red clover grass, or all Pueraria roots. Its medicinal value was first recorded in Shen Nong Ben Cao Jing 2838 BC.?Daidzein, one of the main soy isoflavones, is also the main component of radix puerariae (Gegen) which is the dry root of kudzu leguminous plants. Radix puerariae can reduce fever, produce saliva, and relieve diarrhea. Its chemical composition is complicated, including puerarin, xyloside, soy flavonoids, soybean flavonoid glycosides, beta-sitosterol, daidzin, daidzein. The main effective components are puerarin and daidzein Daidzein is an isoflavone phytoestrogenic compound that has been found in soybeans and other legumes. It binds to estrogen receptor β (ERβ; Ki = 2.8 μM) but not ERα at concentrations up to 1 mM. It is estrogenic in vitro, increasing gene transcription mediated by the estrogen response element (ERE) in a reporter assay in an ERβ-dependent manner (EC50 = 2.8 μM for MCF-7 cells expressing ERβ). Daidzein is an inhibitor of carbonic anhydrase (CA) that is selective for carbonic CAVII and CAXII (Kis = 4.2 and 56 nM, respectively) over CAI, II, and IV (Kis = >10,000, >10,000, and 718.7 nM, respectively). It reduces tumor growth in a PC3 prostate cancer mouse orthotopic model when administered at a dose of 50 mg/kg per day and potentiates the effects of radiation therapy.
Physical properties Appearance: pale-yellow prismatic crystal. Melting point: 315–323?°C. Solubility: soluble in ethanol and ether
Uses Inactive analog of Genistein (Cat. #G350000). Blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity1. Daidzein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv max:250 nm (log e 4.44) Daidzein belongs to the group of isoflavones. Daidzein and other isoflavone compounds, such as genistein, are present in a number of plants and herbs. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as
Indications Daidzein is mainly used for the treatment of hypertension, coronary heart disease, cerebral thrombosis, and vertigo and aids in the treatment of sudden deafness. It can also treat women with menopause syndrome.
Clinical Use Daidzein can expand the coronary artery, femoral artery, and cerebral artery, increase cerebral blood flow and limb blood circulation, reduce blood viscosity and vascular resistance, decrease myocardial oxygen consumption, improve heartfunction, increase the microcirculation and blood flow to the tip, lower the blood pressure, and adjust the heart rhythm. Daidzein can be used for the treatment of hypertension, coronary heart disease, angina pectoris, myocardial infarction, cerebral thrombosis, dizziness, and sudden deafness. It can also be used for women’s menopause syndrome.

Technology Process of Daidzein

There total 70 articles about Daidzein which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%