7-Methoxy-α-(piperidinomethyl)-1-naphthalenemethanol

Base Information

• Chemical Name: 7-Methoxy-α-(piperidinomethyl)-1-naphthalenemethanol
• CAS No.: 63766-09-6
• Molecular Formula: C18H23NO2
• Molecular Weight: 285.3807
• Mol file: 63766-09-6.mol

Synonyms:1-(7-Methoxy-[1]naphthyl)-2-piperidino-aethanol;1-(7-Methoxy-naphthalen-1-yl)-2-piperidin-1-yl-ethanol;

Chemical Property of 7-Methoxy-α-(piperidinomethyl)-1-naphthalenemethanol

Chemical Property:

• Vapor Pressure: 3.6E-09mmHg at 25°C
• Boiling Point: 457.7°Cat760mmHg
• Flash Point: 230.6°C
• PSA: 32.70000
• Density: 1.131g/cm³
• LogP: 3.30560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Methoxy-α-(piperidinomethyl)-1-naphthalenemethanol

There total 3 articles about 7-Methoxy-α-(piperidinomethyl)-1-naphthalenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-[1]naphthoyl chloride (408539-01-5) → 1-(7-methoxy-[1]naphthyl)-2-piperidino-ethanol (63766-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diazomethane; diethyl ether; HBr

2: diethyl ether / Hydrierung des Reaktionsproduktes an Palladium/Kohle in Methanol und wss. Salzsaeure_.

With diazomethane; diethyl ether; hydrogen bromide;

DOI:10.1039/jr9400001307

Reference yield:

7-methoxynaphthalene-1-carboxylic acid (7498-58-0) → 1-(7-methoxy-[1]naphthyl)-2-piperidino-ethanol (63766-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus (V)-chloride

2: diazomethane; diethyl ether; HBr

3: diethyl ether / Hydrierung des Reaktionsproduktes an Palladium/Kohle in Methanol und wss. Salzsaeure_.

With diazomethane; diethyl ether; phosphorus pentachloride; hydrogen bromide;

DOI:10.1039/jr9400001307

Reference yield:

piperidine (110-89-4) + 2-bromo-1-(7-methoxy-[1]naphthyl)-ethanone (860539-33-9) → 1-(7-methoxy-[1]naphthyl)-2-piperidino-ethanol (63766-09-6)

Guidance literature:

With diethyl ether; Hydrierung des Reaktionsproduktes an Palladium/Kohle in Methanol und wss. Salzsaeure_.;

DOI:10.1039/jr9400001307

upstream raw materials:

piperidine

2-bromo-1-(7-methoxy-[1]naphthyl)-ethanone

7-methoxy-[1]naphthoyl chloride

7-methoxynaphthalene-1-carboxylic acid