5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide

Base Information

Chemical Name:5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide
CAS No.:213252-19-8
Molecular Formula:C20H17 F3 N2 O4 S
Molecular Weight:438.427
Hs Code.:
DSSTox Substance ID:DTXSID90870239
Nikkaji Number:J1.055.960J
Wikidata:Q27086690
Pharos Ligand ID:T9HLMZZPATXF
ChEMBL ID:CHEMBL24458
Mol file:213252-19-8.mol

Synonyms:5-((2,4-dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide;KCL1998001079;KRP 297;KRP-297;KRP297;L 410198;L-410198;L410198;MK 767;MK-767;MK767 cpd

Suppliers and Price of 5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-(2,4-DIOXO-THIAZOLIDIN-5-YLMETHYL)-2-METHOXY-N-(4-TRIFLUOROMETHYL-BENZYL)-BENZAMIDE 95.00%
5MG
$ 504.36

Total 4 raw suppliers

Chemical Property of 5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide

Chemical Property:

Vapor Pressure:1.32E-14mmHg at 25°C
Boiling Point:605.4°C at 760 mmHg
Flash Point:319.9°C
PSA：116.78000
Density:1.395g/cm³
LogP:4.38880
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:438.08611269
Heavy Atom Count:30
Complexity:653

Purity/Quality:

97% ^*data from raw suppliers

5-(2,4-DIOXO-THIAZOLIDIN-5-YLMETHYL)-2-METHOXY-N-(4-TRIFLUOROMETHYL-BENZYL)-BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CC2C(=O)NC(=O)S2)C(=O)NCC3=CC=C(C=C3)C(F)(F)F

Technology Process of 5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide

There total 5 articles about 5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(4-Trifluoromethylbenzyl)-5-(2,4-dioxothiazolidin-5-ylidene)methyl-2-methoxybenzamide

: 213252-19-8
N-(4-trifluoromethylbenzyl)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxybenzamide

Guidance literature:: In ethanol;

Reference yield:

: 22802-67-1
methyl 2-methoxy-5-aminobenzoate

: 213252-19-8
N-(4-trifluoromethylbenzyl)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaNO₂, HBr, 2.) Cu₂O / 1.) MeOH, acetone

2: ethanol

3: 6N aq. HCl, sulfolane

4: diethylphosphorocyanidate, Et₃N / dimethylformamide

With copper(I) oxide; sulfolane; hydrogenchloride; diethyl cyanophosphonate; hydrogen bromide; triethylamine; sodium nitrite; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00039-6

Reference yield:

: 186312-73-2
methyl 5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxy-benzoate

: 213252-19-8
N-(4-trifluoromethylbenzyl)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 6N aq. HCl, sulfolane

2: diethylphosphorocyanidate, Et₃N / dimethylformamide

With sulfolane; hydrogenchloride; diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00039-6