2-(2,4-dimethylphenyl)quinoline-4-carboxylic acid

Base Information

• Chemical Name: 2-(2,4-dimethylphenyl)quinoline-4-carboxylic acid
• CAS No.: 5466-33-1
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.323
• Hs Code.: 2933499090
• Mol file: 5466-33-1.mol

Synonyms:2,6-DIMETHOXYISONICOTINIC ACID;2-(2',4'-dimethylphenyl)quinoline-4-carboxylic acid;2-(2,4-Dimethylphenyl)-chinolin-4-carbonsaeure;

Chemical Property of 2-(2,4-dimethylphenyl)quinoline-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 4.6E-09mmHg at 25°C
• Boiling Point: 454.8°Cat760mmHg
• Flash Point: 228.9°C
• PSA: 50.19000
• Density: 1.22g/cm³
• LogP: 4.21680

Purity/Quality:

98%min ^*data from raw suppliers

2-(2,4-Dimethylphenyl)-4-quinolinecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4-dimethylphenyl)quinoline-4-carboxylic acid

There total 2 articles about 2-(2,4-dimethylphenyl)quinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + 2,4-dimethylacetophenone. (89-74-7) → 2-(2,4-dimethyl-phenyl)-quinoline-4-carboxylic acid (5466-33-1)

Guidance literature:

With potassium hydroxide;

Reference yield:

→ 2-(2,4-dimethyl-phenyl)-quinoline-4-carboxylic acid (5466-33-1)

Guidance literature:

Isatin, wss. A., 2,4-Dimethyl-acetophenon (1 Mol), KOH, Sd.;

Reference yield:

2-(2,4-dimethyl-phenyl)-quinoline-4-carboxylic acid (5466-33-1) → 2-(2,4-dimethyl-phenyl)-quinoline-4-carbonyl chloride (883526-18-9)

Guidance literature:

With thionyl chloride; Heating;

DOI:10.1016/j.bmc.2005.11.006

upstream raw materials:

indole-2,3-dione

2,4-dimethylacetophenone.

Downstream raw materials:

2-(2,4-dimethyl-phenyl)-quinoline

2-(2,4-dimethyl-phenyl)-quinoline-4-carbonyl chloride

Refernces

• 1、 -. "QUINOLINE-4-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THE COMPOUNDS". . . Retrieved 2008/06/13.