4-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]morpholine

Base Information

Chemical Name:4-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]morpholine
CAS No.:84466-86-4
Molecular Formula:C₁₀H₂₀N₂O
Molecular Weight:184.282
Hs Code.:
DSSTox Substance ID:DTXSID101228159
Nikkaji Number:J2.095.833B
Mol file:84466-86-4.mol

Synonyms:84466-86-4;SCHEMBL3078767;DTXSID101228159;AKOS006302848;4-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]morpholine

Suppliers and Price of 4-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-4-[(1-METHYL-2-PYRROLIDINYL)METHYL]MORPHOLINE 95.00%
5MG
$ 501.29

Total 3 raw suppliers

Chemical Property of 4-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]morpholine

Chemical Property:

PSA：15.71000
LogP:0.28860
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:184.157563266
Heavy Atom Count:13
Complexity:157

Purity/Quality:: (S)-4-[(1-METHYL-2-PYRROLIDINYL)METHYL]MORPHOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCCC1CN2CCOCC2
Isomeric SMILES:CN1CCC[C@H]1CN2CCOCC2

Technology Process of 4-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]morpholine

There total 4 articles about 4-[[(2S)-1-Methyl-2-pyrrolidinyl]methyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 110-91-8,99108-56-2
morpholine

: 3554-65-2
1-methyl-2-pyrrolidine-methanol

: 84466-86-4
4-[(1-methyl-2-pyrrolidinyl)methyl]morpholine

Guidance literature:: With dichloro(p-cymene)ruthenium(II) dimer; triphenylphosphine; In toluene; at 140 ℃; for 24h; Sealed tube;
DOI:10.1002/ejoc.202000167

Reference yield:

: 537040-24-7
(S)-tert-butyl 2-(morpholine-4-carbonyl)pyrrolidine-1-carboxylate

: 84466-86-4
(S)-1-methyl-2-((morpholin-1-yl)methyl)pyrrolidine

Guidance literature:: (S)-tert-butyl 2-(morpholine-4-carbonyl)pyrrolidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere; Reflux;

With water; rochelle salt; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.04.103

Reference yield:

: C₁₄H₂₆NO₇P

: 84466-86-4
(S)-1-methyl-2-((morpholin-1-yl)methyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 5 h / 70 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux

2.2: 0 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/j.tet.2012.04.103