2-Hexenoic acid, 4-[[(2S)-2-[[(2S)-2,3-dimethyl-1-oxo-3-phenylbutyl]amino]-3,3-dimethyl-1 -oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

Base Information

Chemical Name:2-Hexenoic acid, 4-[[(2S)-2-[[(2S)-2,3-dimethyl-1-oxo-3-phenylbutyl]amino]-3,3-dimethyl-1 -oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-
CAS No.:845292-32-2
Molecular Formula:C29H46N2O4
Molecular Weight:486.695
Hs Code.:

2-Hexenoic acid,
4-[[(2S)-2-[[(2S)-2,3-dimethyl-1-oxo-3-phenylbutyl]amino]-3,3-dimethyl-1
-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

Synonyms:

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Chemical Property of 2-Hexenoic acid, 4-[[(2S)-2-[[(2S)-2,3-dimethyl-1-oxo-3-phenylbutyl]amino]-3,3-dimethyl-1 -oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

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Technology Process of 2-Hexenoic acid, 4-[[(2S)-2-[[(2S)-2,3-dimethyl-1-oxo-3-phenylbutyl]amino]-3,3-dimethyl-1 -oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-

There total 6 articles about 2-Hexenoic acid, 4-[[(2S)-2-[[(2S)-2,3-dimethyl-1-oxo-3-phenylbutyl]amino]-3,3-dimethyl-1 -oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 610786-70-4
ethyl (S,E)-4-((S)-2-amino-N,3,3-trimethylbutanamide)-2,5-dimethylhexa-2-enoate hydrochloride

: 845292-32-2
Ethyl (E,4S)-4-[((2S)-2-{[(2S)-2,3-dimethyl-3-phenylbutanoyl]amino}-3,3-dimethylbutanoyl)(methyl)amino]-2,5-dimethyl-2-hexenoate

Guidance literature:: (2S)-2,3-dimethyl-3-phenylbutanoic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 1h;

ethyl (S,E)-4-((S)-2-amino-N,3,3-trimethylbutanamide)-2,5-dimethylhexa-2-enoate hydrochloride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 22h;

Reference yield:

: 765930-91-4
(2S)-2,3-dimethyl-3-phenylbutanoic acid

: 610786-70-4
ethyl (S,E)-4-((S)-2-amino-N,3,3-trimethylbutanamide)-2,5-dimethylhexa-2-enoate hydrochloride

: 845292-32-2
Ethyl (E,4S)-4-[((2S)-2-{[(2S)-2,3-dimethyl-3-phenylbutanoyl]amino}-3,3-dimethylbutanoyl)(methyl)amino]-2,5-dimethyl-2-hexenoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm040056u

Reference yield:

: 1010-48-6
3-methyl-3-phenylbutanoic acid

: 845292-32-2
Ethyl (E,4S)-4-[((2S)-2-{[(2S)-2,3-dimethyl-3-phenylbutanoyl]amino}-3,3-dimethylbutanoyl)(methyl)amino]-2,5-dimethyl-2-hexenoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / -78 - 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.2: 1.5 g / tetrahydrofuran / 20 h / -78 - 20 °C

3.1: sodium hexamethylsilazide / tetrahydrofuran / 0.5 h / -78 °C

3.2: 71 percent / tetrahydrofuran / 18 h / 20 °C

4.1: 72 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 18 h / 20 °C

5.1: PyBOP; diisopropylethylamine / dimethylformamide / 0 - 20 °C

With lithium hydroxide; n-butyllithium; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dihydrogen peroxide; sodium hexamethyldisilazane; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm040056u