2-Propenoic acid, (2S)-2-[[(4-iodophenyl)methyl](phenylmethyl)amino]-1,1,3-trimethylbutyl ester

Base Information

• Chemical Name: 2-Propenoic acid, (2S)-2-[[(4-iodophenyl)methyl](phenylmethyl)amino]-1,1,3-trimethylbutyl ester
• CAS No.: 845300-67-6
• Molecular Formula: C24H30INO2
• Molecular Weight: 491.412
• Mol file: 845300-67-6.mol

Synonyms:

Chemical Property of 2-Propenoic acid, (2S)-2-[[(4-iodophenyl)methyl](phenylmethyl)amino]-1,1,3-trimethylbutyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, (2S)-2-[[(4-iodophenyl)methyl](phenylmethyl)amino]-1,1,3-trimethylbutyl ester

There total 9 articles about 2-Propenoic acid, (2S)-2-[[(4-iodophenyl)methyl](phenylmethyl)amino]-1,1,3-trimethylbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-{[1-(4-Iodo-phenyl)-meth-(E)-ylidene]-amino}-2,4-dimethyl-pentan-2-ol → Acrylic acid (S)-2-[benzyl-(4-iodo-benzyl)-amino]-1,1,3-trimethyl-butyl ester (845300-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaBH₄ / methanol / 24 h / 20 °C

2.1: NaH / dimethylformamide / 6 h / 20 °C

2.2: 70 percent / dimethylformamide / 16 h / 20 °C

3.1: 74 percent / Et₃N; hydroquinone / CH₂Cl₂ / 2 h / 0 °C

With sodium tetrahydroborate; sodium hydride; triethylamine; hydroquinone; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200400608

Reference yield:

(S)-3-(4-Iodo-benzylamino)-2,4-dimethyl-pentan-2-ol (845300-63-2) → Acrylic acid (S)-2-[benzyl-(4-iodo-benzyl)-amino]-1,1,3-trimethyl-butyl ester (845300-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 6 h / 20 °C

1.2: 70 percent / dimethylformamide / 16 h / 20 °C

2.1: 74 percent / Et₃N; hydroquinone / CH₂Cl₂ / 2 h / 0 °C

With sodium hydride; triethylamine; hydroquinone; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200400608

Reference yield:

4-iodobenzoic acid (619-58-9) → Acrylic acid (S)-2-[benzyl-(4-iodo-benzyl)-amino]-1,1,3-trimethyl-butyl ester (845300-67-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 99 percent / BH₃*THF / tetrahydrofuran / 16 h / 20 °C

2.1: 99 percent / MnO₂ / CHCl₃ / 72 h / Heating

3.1: MgSO₄ / CH₂Cl₂ / 24 h / 20 °C

4.1: NaBH₄ / methanol / 24 h / 20 °C

5.1: NaH / dimethylformamide / 6 h / 20 °C

5.2: 70 percent / dimethylformamide / 16 h / 20 °C

6.1: 74 percent / Et₃N; hydroquinone / CH₂Cl₂ / 2 h / 0 °C

With manganese(IV) oxide; sodium tetrahydroborate; borane-THF; sodium hydride; magnesium sulfate; triethylamine; hydroquinone; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1002/chem.200400608

upstream raw materials:

(S)-3-(4-Iodo-benzylamino)-2,4-dimethyl-pentan-2-ol

4-iodobenzoic acid

4-iodo-benzyl alcohol

N-tert-butoxycarbonyl-L-valine methyl ester