2-bromo-2-5-dihydroxyacetophenone

Base Information

• Chemical Name: 2-bromo-2-5-dihydroxyacetophenone
• CAS No.: 25015-91-2
• Molecular Formula: C8H7 Br O3
• Molecular Weight: 231.046
• Hs Code.: 2914700090
• Mol file: 25015-91-2.mol

Synonyms:Acetophenone,2-bromo-2',5'-dihydroxy- (8CI); 1-(2,5-Dihydroxyphenyl)-2-bromoethanone

Chemical Property of 2-bromo-2-5-dihydroxyacetophenone

Chemical Property:

• Vapor Pressure: 3.33E-06mmHg at 25°C
• Melting Point: 117.5-119.0 °C
• Boiling Point: 376.5°Cat760mmHg
• PKA: 8.21±0.43(Predicted)
• Flash Point: 181.5°C
• PSA: 57.53000
• Density: 1.763g/cm³
• LogP: 1.67540
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2,5-DihydroxyphenacylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-2-5-dihydroxyacetophenone

There total 6 articles about 2-bromo-2-5-dihydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,5-Dihydroxyacetophenone (490-78-8) → 2-bromo-1-(2,5-dihydroxyphenyl)ethanone (25015-91-2)

Guidance literature:

With aluminium trichloride; Montmorillonite K₁₀; bromine; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

1-(2,5-diacetoxy-phenyl)-2-diazo-ethanone (438239-21-5) → 2-bromo-1-(2,5-dihydroxyphenyl)ethanone (25015-91-2)

Guidance literature:

With hydrogen bromide; acetic acid; und Behandeln des Reaktionsprodukts mit methanol. HBr;

DOI:10.1021/jo01119a008

Reference yield:

2,5-diacetoxybenzoyl chloride (37785-02-7) → 2-bromo-1-(2,5-dihydroxyphenyl)ethanone (25015-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene; diethyl ether

2: acetic acid; HBr / und Behandeln des Reaktionsprodukts mit methanol. HBr

With diethyl ether; hydrogen bromide; acetic acid; benzene;

DOI:10.1021/jo01119a008

upstream raw materials:

1-(2,5-diacetoxy-phenyl)-2-diazo-ethanone

2-Bromoacetyl bromide

1,4-dimethoxybezene

2,5-Dihydroxyacetophenone

Downstream raw materials:

1-(5-acetoxy-2-hydroxy-phenyl)-2-bromo-ethanone

2-bromo-1-(2,5-diacetoxy-phenyl)-ethanone

5-hydroxy-2,3-dihydrobenzofuran-3-one

Refernces

• 1、 Fang, Yuanying,Wang, Rikang,Wang, Qi,Sun, Yongbing,Xie, Saisai,Yang, Zunhua,Li, Min,Jin, Yi,Yang, Shilin. "Design and synthesis of novel senkyunolide analogues as neuroprotective agents". . p. 668 - 672. Retrieved 2018/01/27.
• 2、 Lee, Chong-Yew,Chew, Eng-Hui,Go, Mei-Lin. "Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR". experimental part. p. 2957 - 2971. Retrieved 2010/09/03.