Technology Process of 2(1H)-Isoquinolinecarboxylic acid,
3-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-3,4-dihydro-
, 1,1-dimethylethyl ester, (3R)-
There total 7 articles about 2(1H)-Isoquinolinecarboxylic acid,
3-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-3,4-dihydro-
, 1,1-dimethylethyl ester, (3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
ethanol; water;
at 85 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: di-n-butylboryl trifluoromethanesulfonate; triethylamine / dichloromethane / 2 h / -20 - 0 °C
1.2: -78 °C
2.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 8 h / 0 °C
3.1: diphenyl phosphoryl azide; triethylamine / toluene / 4 h / 20 - 80 °C
4.1: lithium hydroxide / ethanol; water / 4 h / 85 °C
With
lithium hydroxide; di-n-butylboryl trifluoromethanesulfonate; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 8 h / 0 °C
2: diphenyl phosphoryl azide; triethylamine / toluene / 4 h / 20 - 80 °C
3: lithium hydroxide / ethanol; water / 4 h / 85 °C
With
lithium hydroxide; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine;
In
tetrahydrofuran; ethanol; water; toluene;