1,3-Oxathiolane-2-methanol,5-(2-amino-6-chloro-9H-purin-9-yl)-, (2S-trans)- (9CI)

Base Information

Chemical Name:1,3-Oxathiolane-2-methanol,5-(2-amino-6-chloro-9H-purin-9-yl)-, (2S-trans)- (9CI)
CAS No.:149819-74-9
Molecular Formula:C₉H₁₀ClN₅O₂S
Molecular Weight:287.73
Hs Code.:
Mol file:149819-74-9.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Oxathiolane-2-methanol,5-(2-amino-6-chloro-9H-purin-9-yl)-, (2S-trans)- (9CI)

Chemical Property:

Boiling Point:660.4°Cat760mmHg
Flash Point:353.2°C
Density:2.03g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,3-Oxathiolane-2-methanol,5-(2-amino-6-chloro-9H-purin-9-yl)-, (2S-trans)- (9CI)

There total 4 articles about 1,3-Oxathiolane-2-methanol,5-(2-amino-6-chloro-9H-purin-9-yl)-, (2S-trans)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: (2S,5RS)-2-amino-6-chloro-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>purine

: 149819-74-9
(+)-(2S,5S)-2-amino-6-chloro-9-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>purine

: 149819-73-8
(-)-(2S,5R)-2-amino-6-chloro-9-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>purine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jm00070a006

Reference yield:

: 1651-29-2
6-chloro-2-fluoropurine

: 149819-74-9
(+)-(2S,5S)-2-amino-6-chloro-9-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>purine

Guidance literature:: Multi-step reaction with 4 steps

1: (NH₄)2SO₄ / CH₂Cl₂ / Ambient temperature

2: 55 percent / trimethylsilyl triflate / CH₂Cl₂ / 4 h / Heating

3: 67 percent / NH₃ (gas) / 1,2-dimethoxy-ethane / Ambient temperature

4: 42 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00070a006

Reference yield:

: 149712-96-9
2-fluoro-6-chloropurine

: 149819-74-9
(+)-(2S,5S)-2-amino-6-chloro-9-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>purine

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / trimethylsilyl triflate / CH₂Cl₂ / 4 h / Heating

2: 67 percent / NH₃ (gas) / 1,2-dimethoxy-ethane / Ambient temperature

3: 42 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00070a006