L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl-L-tyrosyl-L-prolyl-L-phenylalan yl-

Base Information

Chemical Name:L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl-L-tyrosyl-L-prolyl-L-phenylalan yl-
CAS No.:845623-01-0
Molecular Formula:C38H47N5O7
Molecular Weight:685.82
Hs Code.:

Synonyms:

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Chemical Property of L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl-L-tyrosyl-L-prolyl-L-phenylalan yl-

Chemical Property:

Purity/Quality:

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Technology Process of L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl-L-tyrosyl-L-prolyl-L-phenylalan yl-

There total 8 articles about L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl-L-tyrosyl-L-prolyl-L-phenylalan yl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133921-27-4
4-iodo-3-methyl-phenol

: 845623-01-0
Boc-(2'-monomethyltyrosine)-Pro-Phe-Phe-NH₂

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / pyridine / 0.5 h / 50 °C

2: 76.4 percent / tri-o-tolylphosphine; TEA; Pd(OAc)2 / acetonitrile / 10 h / Heating

3: H₂ / [Rh(1,5-COD)(R,R-DIPAMP)]BF₄ / ethyl acetate / 12 h / 60 °C / 3102.89 Torr

4: 4.98 g / aq. HCl / 4.5 h / Heating

5: 96 percent / TEA / dioxane; H₂O / 2.25 h / 0 - 20 °C

6: 120 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With pyridine; hydrogenchloride; palladium diacetate; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; [Rh((R,R)-DIPAMP)(COD)]BF₄; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 2: Heck reaction;
DOI:10.1021/jm049384k

Reference yield:

: 845622-63-1
4-iodo-3-methylphenol acetate

: 845623-01-0
Boc-(2'-monomethyltyrosine)-Pro-Phe-Phe-NH₂

Guidance literature:: Multi-step reaction with 5 steps

1: 76.4 percent / tri-o-tolylphosphine; TEA; Pd(OAc)2 / acetonitrile / 10 h / Heating

2: H₂ / [Rh(1,5-COD)(R,R-DIPAMP)]BF₄ / ethyl acetate / 12 h / 60 °C / 3102.89 Torr

3: 4.98 g / aq. HCl / 4.5 h / Heating

4: 96 percent / TEA / dioxane; H₂O / 2.25 h / 0 - 20 °C

5: 120 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; palladium diacetate; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; [Rh((R,R)-DIPAMP)(COD)]BF₄; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Heck reaction;
DOI:10.1021/jm049384k

Reference yield:

: 845622-69-7
methyl (Z)-2-acetamido-3-(4-acetoxy-2-methylphenyl)-propenoate

: 845623-01-0
Boc-(2'-monomethyltyrosine)-Pro-Phe-Phe-NH₂

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / [Rh(1,5-COD)(R,R-DIPAMP)]BF₄ / ethyl acetate / 12 h / 60 °C / 3102.89 Torr

2: 4.98 g / aq. HCl / 4.5 h / Heating

3: 96 percent / TEA / dioxane; H₂O / 2.25 h / 0 - 20 °C

4: 120 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; [Rh((R,R)-DIPAMP)(COD)]BF₄; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm049384k