Ribavirin 5'-sulfamate

Base Information

Chemical Name:Ribavirin 5'-sulfamate
CAS No.:120615-22-7
Molecular Formula:C₈H₁₃N₅O₇S
Molecular Weight:323.287
Hs Code.:
DSSTox Substance ID:DTXSID60152933
Nikkaji Number:J271.464G
Wikidata:Q83019728
Mol file:120615-22-7.mol

Synonyms:1-(5'-O-sulfamoyl-beta-ribofuranosyl)-(1,2,4)triazole-3-carboxamide;5'-O-sulfamoyl-1-ribofuranosyl-1,2,4-triazole-3-carboxamide;ribavirin 5'-sulfamate

Suppliers and Price of Ribavirin 5'-sulfamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
RIBAVIRIN 5'-SULFAMATE 95.00%
5MG
$ 499.83

Total 1 raw suppliers

Chemical Property of Ribavirin 5'-sulfamate

Chemical Property:

Boiling Point:729.2°Cat760mmHg
Flash Point:394.8°C
PSA：201.26000
Density:2.25g/cm³
LogP:-1.30230
XLogP3:-3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:323.05356894
Heavy Atom Count:21
Complexity:496

Purity/Quality:: RIBAVIRIN 5'-SULFAMATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC(=NN1C2C(C(C(O2)COS(=O)(=O)N)O)O)C(=O)N
Isomeric SMILES:C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)COS(=O)(=O)N)O)O)C(=O)N

Technology Process of Ribavirin 5'-sulfamate

There total 4 articles about Ribavirin 5'-sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 123124-31-2
1-(5'-O-sulfamoyl-2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide

: 120615-22-7
1-(5'-O-sulfamoyl-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide

Guidance literature:: With acetic acid; at 100 ℃; for 2h;
DOI:10.1021/jm00163a008

Reference yield: 93.0%

: 120615-22-7
1-(5'-O-sulfamoyl-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide

Guidance literature:

Reference yield:

: 36791-04-5,66510-90-5
ribavirin

: 120615-22-7
1-(5'-O-sulfamoyl-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / 70percent perchloric acid / acetone / 1.5 h / 0 °C

2: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) a.) 0 deg C, 2 h, b.) RT, 4 h

3: 93 percent / 80percent acetic acid / 2 h / 100 °C

With perchloric acid; sodium hydride; acetic acid; In acetone;
DOI:10.1021/jm00163a008