Pyrazolo(1,5-a)pyrimidine-6-carboxamide, 1,7-dihydro-5-methyl-7-oxo-N,1-di-2-pyridinyl-

Base Information

Chemical Name:Pyrazolo(1,5-a)pyrimidine-6-carboxamide, 1,7-dihydro-5-methyl-7-oxo-N,1-di-2-pyridinyl-
CAS No.:87948-87-6
Molecular Formula:C₁₈H₁₄N₆O₂
Molecular Weight:346.348
Hs Code.:
DSSTox Substance ID:DTXSID70236718
Wikidata:Q83118740

Synonyms:5-Methyl-7-oxo-N,1-di-2-pyridinyl-1,7-dihydropyrazolo(1,5-a)pyrimidine-6-carboxamide;Pyrazolo(1,5-a)pyrimidine-6-carboxamide, 1,7-dihydro-5-methyl-7-oxo-N,1-di-2-pyridinyl-;87948-87-6;DTXSID70236718;LS-129222

Suppliers and Price of Pyrazolo(1,5-a)pyrimidine-6-carboxamide, 1,7-dihydro-5-methyl-7-oxo-N,1-di-2-pyridinyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Pyrazolo(1,5-a)pyrimidine-6-carboxamide, 1,7-dihydro-5-methyl-7-oxo-N,1-di-2-pyridinyl-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.42g/cm³
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:346.11782371
Heavy Atom Count:26
Complexity:698

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)N2C(=N1)C=CN2C3=CC=CC=N3)C(=O)NC4=CC=CC=N4

Technology Process of Pyrazolo(1,5-a)pyrimidine-6-carboxamide, 1,7-dihydro-5-methyl-7-oxo-N,1-di-2-pyridinyl-

There total 5 articles about Pyrazolo(1,5-a)pyrimidine-6-carboxamide, 1,7-dihydro-5-methyl-7-oxo-N,1-di-2-pyridinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 504-29-0
2-aminopyridine

: 87948-37-6
5-methyl-1-(2-pyridyl)-7-oxo-1H,7H-pyrazolo<1,5-a>pyrimidine-6-carboxylic acid ethyl ester

: 87948-87-6
5-methyl-1-(2-pyridyl)-7-oxo-1H,7H-pyrazolo<1,5-a>pyrimidine-6-N-(2-pyridyl)carboxamide

Guidance literature:: With PPA; at 120 ℃; for 2h;

Reference yield:

: 87949-16-4
1-(pyridin-2-yl)-1H-pyrazol-3-amine

: 87948-87-6
5-methyl-1-(2-pyridyl)-7-oxo-1H,7H-pyrazolo<1,5-a>pyrimidine-6-N-(2-pyridyl)carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-acetamide / 3 h / 160 °C

2: polyphosphoric acid, phosphorus oxychloride / 0.5 h / Heating

3: 80 percent / polyphosphoric acid / 2 h / 120 °C

With PPA; trichlorophosphate; In N,N-dimethyl acetamide;

Reference yield:

: 77992-34-8
3-Amino-1-(pyridin-2-yl)-2-pyrazoline

: 87948-87-6
5-methyl-1-(2-pyridyl)-7-oxo-1H,7H-pyrazolo<1,5-a>pyrimidine-6-N-(2-pyridyl)carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 63.8 percent / chloranil / CHCl₃ / 1 h / Ambient temperature

2: N,N-dimethyl-acetamide / 3 h / 160 °C

3: polyphosphoric acid, phosphorus oxychloride / 0.5 h / Heating

4: 80 percent / polyphosphoric acid / 2 h / 120 °C

With PPA; chloranil; trichlorophosphate; In chloroform; N,N-dimethyl acetamide;