5-Chloro-1H-indole-2,3-dione 3-oxime

Base Information

• Chemical Name: 5-Chloro-1H-indole-2,3-dione 3-oxime
• CAS No.: 85124-16-9
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.593
• Mol file: 85124-16-9.mol

Synonyms:5-Chloroisatin 3-oxime;5-chloro-1H-indole-2,3-dione 3-oxime;5-Chlorisatin-3-oxim;1H-Indole-2,3-dione,5-chloro-,3-oxime;5-Chlor-indolin-2,3-dion-3-oxim;EINECS 285-697-1;5-Chlorisatin-3-oxim [German];5-chloro-indoline-2,3-dione-3-oxime;

Chemical Property of 5-Chloro-1H-indole-2,3-dione 3-oxime

Chemical Property:

• Vapor Pressure: 6.46E-05mmHg at 25°C
• Boiling Point: 307.9°C at 760 mmHg
• Flash Point: 140°C
• PSA: 61.69000
• Density: 1.67g/cm³
• LogP: 1.60840

Purity/Quality:

97% ^*data from raw suppliers

(3Z)-5-Chloro-1H-indole-2,3-dione 3-oxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-1H-indole-2,3-dione 3-oxime

There total 4 articles about 5-Chloro-1H-indole-2,3-dione 3-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-nitro-1-(4-chlorophenyl)ethan-1-one (125244-72-6) → 5-Chloroisatin 3-oxime (85124-16-9)

Guidance literature:

With trifluorormethanesulfonic acid; Ambient temperature;

DOI:10.1055/s-1992-26223

Reference yield:

4-chloro-aniline (106-47-8) → 5-Chloroisatin 3-oxime (85124-16-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / aq. ethanol / 24 h / Heating

2: 76 percent / aq.KOH / 5 h / Heating

3: 70 percent / CF₃SO₃H / Ambient temperature

With potassium hydroxide; trifluorormethanesulfonic acid; In ethanol;

DOI:10.1055/s-1992-26223

Reference yield:

(4-Chloro-phenyl)-((E)-1-methylsulfanyl-2-nitro-vinyl)-amine (143884-67-7,1164560-63-7) → 5-Chloroisatin 3-oxime (85124-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / aq.KOH / 5 h / Heating

2: 70 percent / CF₃SO₃H / Ambient temperature

With potassium hydroxide; trifluorormethanesulfonic acid;

DOI:10.1055/s-1992-26223

upstream raw materials:

5-chloroindole 2,3-dione

2-nitro-1-(4-chlorophenyl)ethan-1-one

4-chloro-aniline

(4-Chloro-phenyl)-((E)-1-methylsulfanyl-2-nitro-vinyl)-amine

Downstream raw materials:

2-amino-5-chlorobenzonitrile

5-chloroindole 2,3-dione