3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-5-cyano-1,4-dihydro-2-[[2-[[[4-[(2S)-2-hydroxy-3-[(1- methylethyl)amino]propoxy]phenoxy]acetyl]amino]ethoxy]methyl]-6-meth yl-, ethyl ester

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-5-cyano-1,4-dihydro-2-[[2-[[[4-[(2S)-2-hydroxy-3-[(1- methylethyl)amino]propoxy]phenoxy]acetyl]amino]ethoxy]methyl]-6-meth yl-, ethyl ester
CAS No.:845743-65-9
Molecular Formula:C₃₃H₄₁ClN₄O₇
Molecular Weight:641.164
Hs Code.:

3-Pyridinecarboxylic acid,
4-(2-chlorophenyl)-5-cyano-1,4-dihydro-2-[[2-[[[4-[(2S)-2-hydroxy-3-[(1-
methylethyl)amino]propoxy]phenoxy]acetyl]amino]ethoxy]methyl]-6-meth
yl-, ethyl ester

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-5-cyano-1,4-dihydro-2-[[2-[[[4-[(2S)-2-hydroxy-3-[(1- methylethyl)amino]propoxy]phenoxy]acetyl]amino]ethoxy]methyl]-6-meth yl-, ethyl ester

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Technology Process of 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-5-cyano-1,4-dihydro-2-[[2-[[[4-[(2S)-2-hydroxy-3-[(1- methylethyl)amino]propoxy]phenoxy]acetyl]amino]ethoxy]methyl]-6-meth yl-, ethyl ester

There total 10 articles about 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-5-cyano-1,4-dihydro-2-[[2-[[[4-[(2S)-2-hydroxy-3-[(1- methylethyl)amino]propoxy]phenoxy]acetyl]amino]ethoxy]methyl]-6-meth yl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845744-02-7
ethyl 4-(2-chlorophenyl)-5-cyano-6-methyl-2-[(2-{2-[4-(phenylmethoxy)phenoxy]acetylamino}ethoxy)methyl]-1,4-dihydropyridine-3-carboxylate

: 845743-65-9
ethyl 2-({2-[2-(4-{(2S)-2-hydroxy-3-[(methylethyl)amino]propoxy}phenoxy)acetylamino]ethoxy}methyl)-4-(2-chlorophenyl)-5-cyano-6-metllyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5 % Pd/CaCO3 / methanol / 4 h

With hydrogen; 5 % Pd/CaCO3; In methanol;

Reference yield:

: 845744-01-6
ethyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydro-pyridine-3-carboxylate

: 845743-65-9
ethyl 2-({2-[2-(4-{(2S)-2-hydroxy-3-[(methylethyl)amino]propoxy}phenoxy)acetylamino]ethoxy}methyl)-4-(2-chlorophenyl)-5-cyano-6-metllyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 20 °C

2: hydrogen / 5 % Pd/CaCO3 / methanol / 4 h

With 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5 % Pd/CaCO3; In methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

: 845744-00-5
ethyl 2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate

: 845743-65-9
ethyl 2-({2-[2-(4-{(2S)-2-hydroxy-3-[(methylethyl)amino]propoxy}phenoxy)acetylamino]ethoxy}methyl)-4-(2-chlorophenyl)-5-cyano-6-metllyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine / tetrahydrofuran / 3 h / Heating / reflux

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 20 °C

3: hydrogen / 5 % Pd/CaCO3 / methanol / 4 h

With 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; 5 % Pd/CaCO3; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide);