Carbamic acid, [(2S,3S)-2-[[3-[[5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(trifluorometh yl)phenyl]amino]-1,3-dioxopropyl]amino]-3-hydroxy-4-hexynyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(2S,3S)-2-[[3-[[5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(trifluorometh yl)phenyl]amino]-1,3-dioxopropyl]amino]-3-hydroxy-4-hexynyl]-, phenylmethyl ester
CAS No.:845797-50-4
Molecular Formula:C29H33F3N4O7
Molecular Weight:606.599
Hs Code.:

Carbamic acid,
[(2S,3S)-2-[[3-[[5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(trifluorometh
yl)phenyl]amino]-1,3-dioxopropyl]amino]-3-hydroxy-4-hexynyl]-,
phenylmethyl ester

Synonyms:

Suppliers and Price of Carbamic acid, [(2S,3S)-2-[[3-[[5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(trifluorometh yl)phenyl]amino]-1,3-dioxopropyl]amino]-3-hydroxy-4-hexynyl]-, phenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(2S,3S)-2-[[3-[[5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(trifluorometh yl)phenyl]amino]-1,3-dioxopropyl]amino]-3-hydroxy-4-hexynyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of Carbamic acid, [(2S,3S)-2-[[3-[[5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(trifluorometh yl)phenyl]amino]-1,3-dioxopropyl]amino]-3-hydroxy-4-hexynyl]-, phenylmethyl ester

There total 5 articles about Carbamic acid, [(2S,3S)-2-[[3-[[5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(trifluorometh yl)phenyl]amino]-1,3-dioxopropyl]amino]-3-hydroxy-4-hexynyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845797-49-1
3-(3-(tert-butoxycarbonyl)amino-5-(trifluoromethyl)phenylamino)-3-oxopropanoic acid

: 795307-81-2
(2S,3S)-(2-amino-3-hydroxy-hex-4-ynyl)-carbamic acid benzyl ester

: 845797-50-4
benzyl (2S,3S)-2-(3-(3-(tert-butoxycarbonyl)amino-5-(trifluoromethyl)phenylamino)-3-oxopropanamido)-3-hydroxyhex-4-ynylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In DMF (N,N-dimethyl-formamide); dichloromethane; at 20 ℃; for 14h;

Reference yield:

: C₁₉H₂₄N₂O₅

: 845797-50-4
benzyl (2S,3S)-2-(3-(3-(tert-butoxycarbonyl)amino-5-(trifluoromethyl)phenylamino)-3-oxopropanamido)-3-hydroxyhex-4-ynylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: R-alphine borane / 168 h / Neat (no solvent)

2: trifluoroacetic acid / dichloromethane

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide

With R-alphine borane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.007

Reference yield:

: 186603-76-9
C₁₈H₂₇N₃O₆

: 845797-50-4
benzyl (2S,3S)-2-(3-(3-(tert-butoxycarbonyl)amino-5-(trifluoromethyl)phenylamino)-3-oxopropanamido)-3-hydroxyhex-4-ynylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran

2: R-alphine borane / 168 h / Neat (no solvent)

3: trifluoroacetic acid / dichloromethane

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide

With R-alphine borane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.007