BOC-L-3-THIENYLALANINE DCHA SALT

Base Information

• Chemical Name: BOC-L-3-THIENYLALANINE DCHA SALT
• CAS No.: 83825-42-7
• Molecular Formula: C₁₂H₁₇NO₄S
• Molecular Weight: 271.337
• Hs Code.: 2934999090
• Mol file: 83825-42-7.mol

Synonyms:3-Thiophenepropanoicacid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-,(S)-; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(thien-3-yl)propionic acid

Chemical Property of BOC-L-3-THIENYLALANINE DCHA SALT

Chemical Property:

• Appearance/Colour: yellow viscous liquid.
• Vapor Pressure: 2.51E-08mmHg at 25°C
• Refractive Index: 1.6280 (estimate)
• Boiling Point: 434.7 °C at 760 mmHg
• PKA: 3.85±0.10(Predicted)
• Flash Point: 216.7 °C
• PSA: 103.87000
• Density: 1.243g/cm3
• LogP: 2.65940
• Storage Temp.: Store at 0-5°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-β-(3-thienyl)-Ala-OH (dicyclohexylammonium) salt purum, ≥98.0% (TLC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-L-3-THIENYLALANINE DCHA SALT

There total 3 articles about BOC-L-3-THIENYLALANINE DCHA SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-(thien-3-yl)-DL-alanine (3685-51-6,22574-47-6,152612-27-6) → (2S)-2-[(tert-butoxycarbonyl)amino]-3-(thiophen-3-yl)propanoic acid (83825-42-7,226880-86-0)

Guidance literature:

With aq. alkali;

DOI:10.1007/BF00807581

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + sodium hydrogen + di-tert-butyl dicarbonate (24424-99-5) + 3-(thien-3-yl)-DL-alanine (3685-51-6,22574-47-6,152612-27-6) → (2S)-2-[(tert-butoxycarbonyl)amino]-3-(thiophen-3-yl)propanoic acid (83825-42-7,226880-86-0)

Guidance literature:

In water;

Reference yield:

2-acetylamino-3-[3]thienyl-propionic acid (67206-08-0) → (2S)-2-[(tert-butoxycarbonyl)amino]-3-(thiophen-3-yl)propanoic acid (83825-42-7,226880-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.1 M potassium phosphate buffer / 24 h / 40 °C / acylase I (E_.C_. 3.5.1.14, from Aspergillus melleus), pH: 7.5-8

2: aq. alkali

With potassium phosphate buffer;

DOI:10.1007/BF00807581

upstream raw materials:

di-tert-butyl dicarbonate

3-(thien-3-yl)-DL-alanine

2-acetylamino-3-[3]thienyl-propionic acid

1,4-dioxane