Technology Process of 4-Pyrimidinepropanoic acid, a-[(diphenylmethylene)amino]-, ethyl ester
There total 4 articles about 4-Pyrimidinepropanoic acid, a-[(diphenylmethylene)amino]-, ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl N-diphenylmethylene glycine;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane; toluene;
at -78 ℃;
for 0.5h;
Inert atmosphere;
(pyrimidin-4-yl)methyl methanesulfonate;
In
tetrahydrofuran; hexane; toluene;
at -78 - 20 ℃;
for 17h;
Inert atmosphere;
- Guidance literature:
-
benzhydrylidene aminoacetic acid ethyl ester;
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 0 ℃;
for 0.5h;
4-(bromomethyl)pyrimidine;
In
DMF (N,N-dimethyl-formamide);
at 0 - 20 ℃;
for 15h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dichloromethane / 18 h / 20 °C
2.1: lithium diisopropyl amide / toluene; tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 17 h / -78 - 20 °C / Inert atmosphere
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
