1,3-Benzenedicarboxamide, N'-[(1S,2S)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-2-[4-(phenylmethyl) -2-pyridinyl]ethyl]-5-methyl-N,N-dipropyl-

Base Information

Chemical Name:1,3-Benzenedicarboxamide, N'-[(1S,2S)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-2-[4-(phenylmethyl) -2-pyridinyl]ethyl]-5-methyl-N,N-dipropyl-
CAS No.:845973-08-2
Molecular Formula:C₃₆H₃₉F₂N₃O₃
Molecular Weight:599.721
Hs Code.:

1,3-Benzenedicarboxamide,
N'-[(1S,2S)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-2-[4-(phenylmethyl)
-2-pyridinyl]ethyl]-5-methyl-N,N-dipropyl-

Synonyms:

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Chemical Property of 1,3-Benzenedicarboxamide, N'-[(1S,2S)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-2-[4-(phenylmethyl) -2-pyridinyl]ethyl]-5-methyl-N,N-dipropyl-

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Technology Process of 1,3-Benzenedicarboxamide, N'-[(1S,2S)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-2-[4-(phenylmethyl) -2-pyridinyl]ethyl]-5-methyl-N,N-dipropyl-

There total 11 articles about 1,3-Benzenedicarboxamide, N'-[(1S,2S)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-2-[4-(phenylmethyl) -2-pyridinyl]ethyl]-5-methyl-N,N-dipropyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845543-61-5
(S)-N,N-dibenzyl-3,5-difluorophenyl-alaninal

: 845973-08-2
C₃₆H₃₉F₂N₃O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; 2-(N,N-dimethylamino)ethanol / hexane / 1.5 h / -78 °C

1.2: 0.5 h / -78 - 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 110 °C

3.1: hydrogen / palladium hydroxide on carbon / ethanol / 24 h / 20 °C / 760.05 Torr

4.1: 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine / DMF (N,N-dimethyl-formamide) / 22 h / 20 °C

With n-butyllithium; 2-(N,N-dimethylamino)ethanol; hydrogen; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide on carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; hexane;

Reference yield:

: 473567-47-4
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-difluorophenyl)propanoate

: 845973-08-2
C₃₆H₃₉F₂N₃O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 4 h / 0 - 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 24 h / 20 - 70 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.67 h / -78 °C

4.2: 2 h / 20 °C

5.1: n-butyllithium; 2-(N,N-dimethylamino)ethanol / hexane / 1.5 h / -78 °C

5.2: 0.5 h / -78 - 0 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 110 °C

7.1: hydrogen / palladium hydroxide on carbon / ethanol / 24 h / 20 °C / 760.05 Torr

8.1: 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine / DMF (N,N-dimethyl-formamide) / 22 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; 2-(N,N-dimethylamino)ethanol; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); ethanol; hexane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 845543-99-9
C₂₈H₂₅ClF₂N₂O

: 845973-08-2
C₃₆H₃₉F₂N₃O₃

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 110 °C

2: hydrogen / palladium hydroxide on carbon / ethanol / 24 h / 20 °C / 760.05 Torr

3: 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine / DMF (N,N-dimethyl-formamide) / 22 h / 20 °C

With hydrogen; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide on carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol;