Technology Process of 1-Piperazinecarboxylic acid,
2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy
propyl]-3-oxo-4-(phenylmethyl)-6-(2-propenyl)-, 1,1-dimethylethyl ester,
(6S)-
There total 11 articles about 1-Piperazinecarboxylic acid,
2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy
propyl]-3-oxo-4-(phenylmethyl)-6-(2-propenyl)-, 1,1-dimethylethyl ester,
(6S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 4 h / 0 - 20 °C
2.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 24 h / 20 - 70 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.67 h / -78 °C
4.2: 2 h / 20 °C
5.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
With
hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; sodium hydrogencarbonate; dimethyl sulfoxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 2 h / 65 °C
2: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
With
caesium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide);
