1-Piperazinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-[[3-[[(2R)-2-(methoxymeth yl)-1-pyrrolidinyl]carbonyl]-5-methylbenzoyl]amino]propyl]-4-(phenylmeth yl)-, 1,1-dimethylethyl ester, (2R)-

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-[[3-[[(2R)-2-(methoxymeth yl)-1-pyrrolidinyl]carbonyl]-5-methylbenzoyl]amino]propyl]-4-(phenylmeth yl)-, 1,1-dimethylethyl ester, (2R)-
CAS No.:845973-54-8
Molecular Formula:C40H50F2N4O6
Molecular Weight:720.857
Hs Code.:

1-Piperazinecarboxylic acid,
2-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-[[3-[[(2R)-2-(methoxymeth
yl)-1-pyrrolidinyl]carbonyl]-5-methylbenzoyl]amino]propyl]-4-(phenylmeth
yl)-, 1,1-dimethylethyl ester, (2R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-[[3-[[(2R)-2-(methoxymeth yl)-1-pyrrolidinyl]carbonyl]-5-methylbenzoyl]amino]propyl]-4-(phenylmeth yl)-, 1,1-dimethylethyl ester, (2R)-

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Technology Process of 1-Piperazinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-[[3-[[(2R)-2-(methoxymeth yl)-1-pyrrolidinyl]carbonyl]-5-methylbenzoyl]amino]propyl]-4-(phenylmeth yl)-, 1,1-dimethylethyl ester, (2R)-

There total 9 articles about 1-Piperazinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-[[3-[[(2R)-2-(methoxymeth yl)-1-pyrrolidinyl]carbonyl]-5-methylbenzoyl]amino]propyl]-4-(phenylmeth yl)-, 1,1-dimethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1042903-72-9
3-(2-methoxymethyl-pyrrolidine-1-carbonyl)-5-methyl-benzoic acid

: 845546-59-0
C₂₅H₃₃F₂N₃O₃

: 845973-54-8
C₄₀H₅₀F₂N₄O₆

Guidance literature:: With 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 845543-61-5
(S)-N,N-dibenzyl-3,5-difluorophenyl-alaninal

: 845973-54-8
C₄₀H₅₀F₂N₄O₆

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: -78 - 20 °C

2.1: hydrogen / palladium hydroxide on carbon; acetic acid / ethanol / 5 h / 20 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 60 °C / Heating

4.1: 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 20 °C

With n-butyllithium; dimethylsulfide borane complex; hydrogen; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine; diisopropylamine; palladium hydroxide on carbon; acetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane;

Reference yield:

: 473567-47-4
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-difluorophenyl)propanoate

: 845973-54-8
C₄₀H₅₀F₂N₄O₆

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 4 h / 0 - 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 24 h / 20 - 70 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.67 h / -78 °C

4.2: 2 h / 20 °C

5.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 °C

5.2: -78 - 20 °C

6.1: hydrogen / palladium hydroxide on carbon; acetic acid / ethanol / 5 h / 20 °C

7.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 60 °C / Heating

8.1: 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; dimethylsulfide borane complex; hydrogen; sodium hydrogencarbonate; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; diisopropylamine; palladium hydroxide on carbon; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide;