1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-[(trimeth ylsilyl)oxy]propyl]-5-methyl-, 1,1-dimethylethyl ester, (2R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-[(trimeth ylsilyl)oxy]propyl]-5-methyl-, 1,1-dimethylethyl ester, (2R)-
CAS No.:845973-72-0
Molecular Formula:C36H48F2N2O3Si
Molecular Weight:622.871
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-[(trimeth
ylsilyl)oxy]propyl]-5-methyl-, 1,1-dimethylethyl ester, (2R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-[(trimeth ylsilyl)oxy]propyl]-5-methyl-, 1,1-dimethylethyl ester, (2R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-[(trimeth ylsilyl)oxy]propyl]-5-methyl-, 1,1-dimethylethyl ester, (2R)-

There total 10 articles about 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-[(trimeth ylsilyl)oxy]propyl]-5-methyl-, 1,1-dimethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₈F₂N₂O₄Si

: 845973-72-0
C₃₆H₄₈F₂N₂O₃Si

Guidance literature:: With CuBr-DMS; boron trifluoride diethyl etherate; methylmagnesium bromide; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

Reference yield:

: 473567-47-4
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-difluorophenyl)propanoate

: 845973-72-0
C₃₆H₄₈F₂N₂O₃Si

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 4 h / 0 - 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 24 h / 20 - 70 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.67 h / -78 °C

4.2: 2 h / 20 °C

5.1: boron trifluoride diethyl etherate / diethyl ether / 4 h / -78 °C

6.1: sodium tetrahydroborate; nickel dichloride / methanol / 1.5 h / 0 °C

7.1: pyridine / 6 h / 0 °C

8.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2.5 h / -78 °C

9.1: toluene-4-sulfonic acid / 18 h / 20 °C

10.1: CuBr-DMS; boron trifluoride diethyl etherate; methylmagnesium bromide / tetrahydrofuran / 3 h / -78 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; CuBr-DMS; boron trifluoride diethyl etherate; methylmagnesium bromide; diisobutylaluminium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; nickel dichloride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 845543-61-5
(S)-N,N-dibenzyl-3,5-difluorophenyl-alaninal

: 845973-72-0
C₃₆H₄₈F₂N₂O₃Si

Guidance literature:: Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / diethyl ether / 4 h / -78 °C

2: sodium tetrahydroborate; nickel dichloride / methanol / 1.5 h / 0 °C

3: pyridine / 6 h / 0 °C

4: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2.5 h / -78 °C

5: toluene-4-sulfonic acid / 18 h / 20 °C

6: CuBr-DMS; boron trifluoride diethyl etherate; methylmagnesium bromide / tetrahydrofuran / 3 h / -78 - 20 °C

With sodium tetrahydroborate; CuBr-DMS; boron trifluoride diethyl etherate; methylmagnesium bromide; diisobutylaluminium hydride; nickel dichloride; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; diethyl ether; toluene;