acetaldophosphamide

Base Information

• Chemical Name: acetaldophosphamide
• CAS No.: 113341-60-9
• Molecular Formula: C11H21 Cl2 N2 O6 P
• Molecular Weight: 379.177
• Mol file: 113341-60-9.mol

Synonyms:Acetaldophosphamide

Chemical Property of acetaldophosphamide

Chemical Property:

• Vapor Pressure: 8.77E-10mmHg at 25°C
• Melting Point: 51 °C(Solv: ethyl ether (60-29-7); acetone (67-64-1))
• Boiling Point: 490.9°Cat760mmHg
• PKA: 1.02±0.70(Predicted)
• Flash Point: 250.7°C
• PSA: 117.97000
• Density: 1.346g/cm³
• LogP: 2.39210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of acetaldophosphamide

There total 2 articles about acetaldophosphamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3,3-diacetoxypropyl N,N-bis(2-chloroethyl)phosphoramidochloridate (123824-14-6) → 3,3-diacetoxypropyl N,N-bis(2-chloroethyl)phosphorodiamidate (113341-60-9)

Guidance literature:

With ammonium hydroxide; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm00105a030

Reference yield:

C7H11Cl2O6P (123824-13-5) → 3,3-diacetoxypropyl N,N-bis(2-chloroethyl)phosphorodiamidate (113341-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 71 percent / 1 N NH₃ / CH₂Cl₂ / 1 h / Ambient temperature

With ammonium hydroxide; triethylamine; In dichloromethane;

DOI:10.1021/jm00105a030

Reference yield:

3,3-diacetoxypropyl N,N-bis(2-chloroethyl)phosphorodiamidate (113341-60-9) → phosphoramide mustard (10159-53-2) + acrolein (107-02-8,25068-14-8)

Guidance literature:

With phosphate buffer; at 37 ℃; pH 7.4, other acetal diacetates; half-life, effect of hog liver carboxylate esterase;

DOI:10.1021/jm00105a030

upstream raw materials:

3,3-diacetoxypropyl N,N-bis(2-chloroethyl)phosphoramidochloridate

C₇H₁₁Cl₂O₆P

Downstream raw materials:

phosphoramide mustard

acrolein