1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]butoxy]-3,4-dihydro-

Base Information

Chemical Name:1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]butoxy]-3,4-dihydro-
CAS No.:846031-29-6
Molecular Formula:C₂₃H₂₉ClN₄O₂
Molecular Weight:428.962
Hs Code.:

Synonyms:

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Chemical Property of 1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]butoxy]-3,4-dihydro-

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Technology Process of 1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]butoxy]-3,4-dihydro-

There total 6 articles about 1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]butoxy]-3,4-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141-86-6
2.6-diaminopyridine

: 846031-29-6
C₂₃H₂₉ClN₄O₂

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid

2: pyridine; hydrogen fluoride; sodium nitrite

3: potassium tert-butylate; tetrabutylammomium bromide / tetrahydrofuran

4: palladium on carbon; hydrogen / methanol

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 80 °C

6: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

With pyridine; sulfuric acid; palladium on carbon; hydrogen fluoride; potassium tert-butylate; tetrabutylammomium bromide; hydrogen; sodium tris(acetoxy)borohydride; sodium nitrite; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.01.059

Reference yield:

: 632620-24-7
7-Amino-1H-[1,8]naphthyridin-2-one sulfate

: 846031-29-6
C₂₃H₂₉ClN₄O₂

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; hydrogen fluoride; sodium nitrite

2: potassium tert-butylate; tetrabutylammomium bromide / tetrahydrofuran

3: palladium on carbon; hydrogen / methanol

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 80 °C

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

With pyridine; palladium on carbon; hydrogen fluoride; potassium tert-butylate; tetrabutylammomium bromide; hydrogen; sodium tris(acetoxy)borohydride; sodium nitrite; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.01.059

Reference yield:

: 846031-25-2
7-(4-hydroxybutoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

: 846031-29-6
C₂₃H₂₉ClN₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 80 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

With sodium tris(acetoxy)borohydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.01.059