Tiflamizole

Base Information

• Chemical Name: Tiflamizole
• CAS No.: 62894-89-7
• Molecular Formula: C17H10F6N2O2S
• Molecular Weight: 420.3289
• Mol file: 62894-89-7.mol

Synonyms:Tiflamizolum [INN-Latin];4,5-bis-(4-fluoro-phenyl)-2-(1,1,2,2-tetrafluoro-ethanesulfonyl)-1H-imidazole;Tiflamizol [INN-Spanish];TIFLAMIZOLE;Tiflamizolum;4,5-bis-(4-fluorophenyl)-2-[(1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole;4,5-Bis(p-fluorophenyl)-2-((1,1,2,2-tetrafluoroethyl)sulfonyl)imidazole;4,5-bis(4-fluorophenyl)-2-(1,1,2,2-tetrafluoroethylsulfonyl)imidazole;Tiflamizol;

Chemical Property of Tiflamizole

Chemical Property:

• Vapor Pressure: 9.11E-10mmHg at 25°C
• Boiling Point: 490.5°Cat760mmHg
• Flash Point: 250.4°C
• PSA: 71.20000
• Density: 1.498g/cm³
• LogP: 5.73430

Purity/Quality:

97% ^*data from raw suppliers

TIFLAMIZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tiflamizole is an antiinflammatory agent which may assist in the treatment of arthritis.

Technology Process of Tiflamizole

There total 2 articles about Tiflamizole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-bis(4-fluorophenyl)-2-<(1,1,2,2-tetrafluoroethyl)-thio>-1H-imidazole (62894-59-1) → 4,5-bis-(4-fluorophenyl)-2-[(1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole (62894-89-7)

Guidance literature:

With sodium perborate; acetic acid; at 40 ℃; for 12h;

DOI:10.1080/00397919308009837

Reference yield:

→ 4,5-bis-(4-fluorophenyl)-2-[(1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole (62894-89-7)

Guidance literature:

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) + 4,5-bis-(4-fluorophenyl)-2-[(1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole (62894-89-7) → 4,5-bis-(4-fluorophenyl)-1-(4-nitrobenzyl)-2-[(1,1,2,2-tetrafluoroethyl)sulfonyl]-1H-imidazole

Guidance literature:

With potassium carbonate; In N-methyl-acetamide; dichloromethane; water; toluene;

upstream raw materials:

4,5-bis(4-fluorophenyl)-2-<(1,1,2,2-tetrafluoroethyl)-thio>-1H-imidazole

Downstream raw materials:

4,5-bis-(4-fluoro-phenyl)-1-methyl-2-(1,1,2,2-tetrafluoro-ethanesulfonyl)-1H-imidazole

2,2-dimethyl-propionic acid 4,5-bis-(4-fluoro-phenyl)-2-(1,1,2,2-tetrafluoro-ethanesulfonyl)-imidazol-1-ylmethyl ester

Refernces

• 1、 -. "Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones". . . Retrieved 2008/06/13.